Motor activation in multiple system atrophy and Parkinson disease: a PET study
- PMID: 20876470
- DOI: 10.1212/WNL.0b013e3181f4d78f
Motor activation in multiple system atrophy and Parkinson disease: a PET study
Abstract
Background: Multiple system atrophy (MSA) is an atypical parkinsonian syndrome including cerebellar impairment and poor response to levodopa. We assessed right hand motor activation in patients with MSA before and after an acute levodopa challenge in comparison with patients with PD and healthy volunteers (HVs).
Methods: Eighteen patients with MSA, 8 patients with PD, and 10 age-matched HVs were included. Regional cerebral blood flow measurements with H(2)(15)O PET were performed at rest and during a right hand movement. Statistical parametric mapping was used to analyze motor vs rest in OFF and ON conditions and the effect of levodopa on motor activation.
Results: Before levodopa, patients with MSA activated most known cerebral motor areas. Compared with HVs, patients with MSA exhibited less bilateral cerebellar activation and greater left superior parietal activation. They also had less bilateral cerebellar and greater supplementary motor and left superior parietal activation than patients with PD. Conversely, patients with PD had greater activation than HVs in the right cerebellum and less in the supplementary motor cortex. After levodopa, patients with MSA exhibited reduced activation in anterior cingulate, whereas patients with PD had greater activation in the right cerebellum.
Conclusion: Patients with MSA and patients with PD recruited different motor networks. Patients with PD preferentially activated cerebellar pathways, possibly to compensate for basal ganglia dysfunction. This was not observed in patients with MSA, probably because of cerebellar dysfunction; other frontoparietal cortical areas were recruited.
Similar articles
-
Subcortical atrophy and perfusion patterns in Parkinson disease and multiple system atrophy.Parkinsonism Relat Disord. 2020 Mar;72:49-55. doi: 10.1016/j.parkreldis.2020.02.009. Epub 2020 Feb 21. Parkinsonism Relat Disord. 2020. PMID: 32109737
-
Comparison of cerebral glucose metabolism between multiple system atrophy Parkinsonian type and Parkinson's disease.Neurol Res. 2008 May;30(4):377-82. doi: 10.1179/174313208X300396. Neurol Res. 2008. PMID: 18544255
-
Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries.Neuroscience. 2007 Jun 15;147(1):224-35. doi: 10.1016/j.neuroscience.2007.04.006. Epub 2007 May 17. Neuroscience. 2007. PMID: 17499933 Free PMC article.
-
Functional imaging of Parkinson's disease: is it possible to detect brain areas for specific symptoms?J Neural Transm Suppl. 1999;56:139-53. doi: 10.1007/978-3-7091-6360-3_8. J Neural Transm Suppl. 1999. PMID: 10370908 Review.
-
Consensus statement on the diagnosis of multiple system atrophy. American Autonomic Society and American Academy of Neurology.Clin Auton Res. 1998 Dec;8(6):359-62. doi: 10.1007/BF02309628. Clin Auton Res. 1998. PMID: 9869555 Review.
Cited by
-
Bereitschaftspotential in Multiple System Atrophy.Front Neurol. 2021 Jun 2;12:608322. doi: 10.3389/fneur.2021.608322. eCollection 2021. Front Neurol. 2021. PMID: 34149586 Free PMC article.
-
Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Mov Disord. 2021 May;36(5):1180-1190. doi: 10.1002/mds.28468. Epub 2021 Jan 11. Mov Disord. 2021. PMID: 33427336 Free PMC article.
-
Cerebellar atrophy and its contribution to motor and cognitive performance in multiple system atrophy.Neuroimage Clin. 2019;23:101891. doi: 10.1016/j.nicl.2019.101891. Epub 2019 Jun 6. Neuroimage Clin. 2019. PMID: 31226621 Free PMC article.
-
Effects of Multi-Session Repetitive Transcranial Magnetic Stimulation on Motor Control and Spontaneous Brain Activity in Multiple System Atrophy: A Pilot Study.Front Behav Neurosci. 2018 May 9;12:90. doi: 10.3389/fnbeh.2018.00090. eCollection 2018. Front Behav Neurosci. 2018. PMID: 29867391 Free PMC article.
-
Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease.JAMA Neurol. 2017 Sep 1;74(9):1088-1096. doi: 10.1001/jamaneurol.2017.1200. JAMA Neurol. 2017. PMID: 28672395 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous