November 14, 2023, Vol 330, No. 18, Pages 1715-1810

In This Issue of JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2023;330(18):e2216115. doi:10.1001/jama.2022.16115

Audio: Vitamin C for COVID-19, Stool Test for Colorectal Cancer Screening, USPSTF on Oral Health, and more

Original Investigation

Caring for the Critically Ill Patient

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

The LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators

Abstract Full Text

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JAMA. 2023;330(18):1745-1759. doi:10.1001/jama.2023.21407

Two randomized clinical trials were harmonized to compare the effect of vitamin C vs control on outcomes in hospitalized patients with COVID-19 who were critically ill or who were not critically ill.

Editorial
Vitamin C for Patients With COVID-19: More Evidence of Lack of Efficacy in Patients With Sepsis
Craig S. Jabaley, MD; Craig M. Coopersmith, MD

JAMA

Multitarget Stool RNA Test for Colorectal Cancer Screening

Erica K. Barnell, MD, PhD; Elizabeth M. Wurtzler, PhD; Julie La Rocca, MS; et al.

Abstract Full Text

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JAMA. 2023;330(18):1760-1768. doi:10.1001/jama.2023.22231

This article presents results from a prospective pivotal study in which individuals completed a multitarget stool RNA test prior to undergoing a colonoscopy to determine the sensitivity for detecting colorectal cancer and advanced ademonas.

Brief Report

Prevalence of Acinetobacter baumannii and Candida auris in Patients Receiving Mechanical Ventilation

Anthony D. Harris, MD, MPH; Lisa Pineles, MA; J. Kristie Johnson, PhD; et al.

Abstract Full Text

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JAMA. 2023;330(18):1769-1772. doi:10.1001/jama.2023.21083

This cross-sectional study describes the prevalence of Acinetobacter baumannii and Candida auris among patients receiving mechanical ventilation in hospitals and long-term care facilities in Maryland.

Research Letter

Influenza Antiviral Shortages Reported by State and Territorial Public Health Officials, 2022-2023

Noah Kojima, MD; Lisa Peterson, MPH, MPA; Regina Hawkins, MPH; et al.

Abstract Full Text

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JAMA. 2023;330(18):1793-1795. doi:10.1001/jama.2023.17244

This study provides survey results from state and territorial public health preparedness directors regarding antiviral shortages during the 2022-2023 respiratory viral season.

Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss

Mohit Sodhi, MSc; Ramin Rezaeianzadeh, BSc; Abbas Kezouh, PhD; et al.

Abstract Full Text

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JAMA. 2023;330(18):1795-1797. doi:10.1001/jama.2023.19574

This database study examines the association between glucagon-like peptide 1 agonists (eg, semaglutide, liraglutide) used for weight loss and reports of gastrointestinal adverse events.

US Medical Student Plans to Practice in Underserved Areas

Liselotte N. Dyrbye, MD, MHPE; Danielle E. Brushaber, BS; Colin P. West, MD, PhD

Abstract Full Text

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JAMA. 2023;330(18):1797-1799. doi:10.1001/jama.2023.19521

This study explores US medical students’ intent to practice in underserved areas, analyzed by demographic characteristics.

US Preventive Services Task Force

Recommendation Statement

Screening and Preventive Interventions for Oral Health in Adults: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

Abstract Full Text

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JAMA. 2023;330(18):1773-1779. doi:10.1001/jama.2023.21409

This 2023 Recommendation Statement from the US Preventive Services Task Force concludes that the current evidence is insufficient to assess the balance of benefits and harms of routine screening and preventive interventions performed by primary care clinicians for oral health conditions, including dental caries, in adults (I statement).

Audio: USPSTF Recommendations: Screening and Preventive Interventions for Oral Health in Adults and in Children and Adolescents Aged 5 to 17 Years

Editorial
A Call for More Oral Health Research in Primary Care
Michael S. Reddy, DMD, DMSc; Rena N. D’Souza, DDS, MS, PhD; Jennifer Webster-Cyriaque, DDS, PhD

JAMA
- Audio: USPSTF Recommendations: Screening and Preventive Interventions for Oral Health in Adults and in Children and Adolescents Aged 5 to 17 Years

Evidence Report

Screening, Referral, Behavioral Counseling, and Preventive Interventions for Oral Health in Adults: A Systematic Review for the US Preventive Services Task Force

Roger Chou, MD; Shelley S. Selph, MD, MPH; Christina Bougatsos, MPH; et al.

Abstract Full Text

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JAMA. 2023;330(18):1780-1790. doi:10.1001/jama.2023.20685

This systematic review to support the 2023 US Preventive Services Task Force Recommendation Statement on oral health screening and prevention in adults summarizes published evidence on the benefits and harms of screening, referral, behavioral counseling, and preventive interventions for oral health in asymptomatic adults 18 years or older.

Audio: USPSTF Recommendations: Screening and Preventive Interventions for Oral Health in Adults and in Children and Adolescents Aged 5 to 17 Years

Editorial
A Call for More Oral Health Research in Primary Care
Michael S. Reddy, DMD, DMSc; Rena N. D’Souza, DDS, MS, PhD; Jennifer Webster-Cyriaque, DDS, PhD

JAMA
- Audio: USPSTF Recommendations: Screening and Preventive Interventions for Oral Health in Adults and in Children and Adolescents Aged 5 to 17 Years

Viewpoint

PEPFAR Reauthorization by Congress Urgent for Global Health

Monica Gandhi, MD, MPH; Eric Goosby, MD

Abstract Full Text

JAMA. 2023;330(18):1727-1728. doi:10.1001/jama.2023.19322

This Viewpoint discusses the importance of the US Congress reauthorizing funding for the President’s Emergency Plan for AIDS Relief, a program developed in 2003 that has played a critical role in fighting HIV/AIDS worldwide as well as other emerging infections and noncommunicable diseases.

Addressing the Public Health Crisis of Maternal Mortality: A National Research Agenda

Diana W. Bianchi, MD; Janine A. Clayton, MD; Shannon N. Zenk, PhD, MPH, RN

Abstract Full Text

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JAMA. 2023;330(18):1729-1730. doi:10.1001/jama.2023.21294

This Viewpoint discusses the National Institutes of Health initiative that focuses on research that reduces preventable maternal mortality, decreases severe maternal morbidity, and promotes health equity.

Video: Worsening US Maternal Death Rates

Audio: Worsening US Maternal Death Rates

Measuring US Maternal Mortality

Eugene Declercq, PhD; Marie Thoma, PhD

Abstract Full Text

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JAMA. 2023;330(18):1731-1732. doi:10.1001/jama.2023.19945

This Viewpoint discusses the importance of collaboration among the agencies responsible for documenting rates of maternal mortality to ensure more accurate, reliable, and timely estimates.

Video: Worsening US Maternal Death Rates

Audio: Worsening US Maternal Death Rates

Fitness Trackers to Guide Advice on Activity Prescription

I-Min Lee, MBBS, ScD; Sarah K. Keadle, PhD; Charles E. Matthews, PhD

Abstract Full Text

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JAMA. 2023;330(18):1733-1734. doi:10.1001/jama.2023.19332

This Viewpoint discusses whether older self-report questionnaire studies and newer studies of fitness-tracking devices reach different conclusions about the dose of physical activity needed for health.

Audio: Fitness Trackers to Guide Advice on Activity Prescription

AI in Medicine

The Electronic Inbox—Benefits, Questions, and Solutions for the Road Ahead

Lisa S. Rotenstein, MD, MBA, MSc; Adam Landman, MD, MS, MIS, MHS; David W. Bates, MD, MSc

Abstract Full Text

JAMA. 2023;330(18):1735-1736. doi:10.1001/jama.2023.19195

This Viewpoint looks at digital communication between patients and physicians, including approaches to provide adequate support for these efforts that balance patient needs with appropriate time investments from clinicians.

A Piece of My Mind

Something Magical

Iyesatta Massaquoi Emeli, MD, MPH

Abstract Full Text

JAMA. 2023;330(18):1737-1738. doi:10.1001/jama.2023.20706

In this narrative medicine essay, an emergency medicine physician felt the full embrace of health care but not before she surmounted communication barriers that could have negatively affected her health.

Editorial

Vitamin C for Patients With COVID-19: More Evidence of Lack of Efficacy in Patients With Sepsis

Craig S. Jabaley, MD; Craig M. Coopersmith, MD

Abstract Full Text

JAMA. 2023;330(18):1739-1741. doi:10.1001/jama.2023.18592

Decolonization Strategies to Prevent Staphylococcal Infections: Mupirocin by a Nose

Thomas R. Talbot, MD, MPH

Abstract Full Text

JAMA. 2023;330(18):1742-1744. doi:10.1001/jama.2023.4852

JAMA Clinical Guidelines Synopsis

Topical Therapies for Atopic Dermatitis

Amy Z. Xu, MD, MA; Jason T. Alexander, MD

Abstract Full Text

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JAMA. 2023;330(18):1791-1792. doi:10.1001/jama.2023.17719

This JAMA Clinical Guidelines Synopsis summarizes the American Academy of Dermatology’s 2023 guidelines for topical-therapy management of adults with atopic dermatitis.

Editor's Note

What’s in a Name?

Rafael Campo, MD, MA

Abstract Full Text

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JAMA. 2023;330(18):1806. doi:10.1001/jama.2023.19948

Medical News & Perspectives

AI in Medicine

Kaiser Permanente’s CMO: How AI Might Help Clinicians Address Patients’ Social Risk Factors

Rebecca Voelker, MSJ; Yulin Hswen, ScD, MPH

Abstract Full Text

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JAMA. 2023;330(18):1717-1719. doi:10.1001/jama.2023.19294

In this Medical News article, Andrew Bindman, MD, executive vice president and chief medical officer for Kaiser Permanente, discusses how AI can alert clinicians when patients are falling through the health care system’s cracks.

Video: AI and Clinical Practice—Building Patient and Clinician Trust in a Health Care System

Audio: AI and Clinical Practice—Building Patient and Clinician Trust in a Health Care System

Editorial
AI in Medicine—JAMA’s Focus on Clinical Outcomes, Patient-Centered Care, Quality, and Equity
Rohan Khera, MD, MS; Atul J. Butte, MD, PhD; Michael Berkwits, MD, MSCE; Yulin Hswen, ScD, MPH; Annette Flanagin, RN, MA; Hannah Park; Gregory Curfman, MD; Kirsten Bibbins-Domingo, PhD, MD, MAS

JAMA

Critics Say New State “Conscience Laws” Give Physicians Carte Blanche to Refuse Patients

Rita Rubin, MA

Abstract Full Text

JAMA. 2023;330(18):1720-1722. doi:10.1001/jama.2023.19290

This Medical News feature discusses state laws that protect physicians who refuse to provide certain services because of religious or moral beliefs.

Medical News in Brief

Primary Care Telemedicine Outcomes Similar to In-Person Visits in 2021

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1723. doi:10.1001/jama.2023.20628

Study: Carbohydrate Quality Matters for Body Weight

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1723. doi:10.1001/jama.2023.20629

LSD Use Increasing More Among People With Depression

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1723. doi:10.1001/jama.2023.20630

Antiseptic Soap, Nasal Spray Reduced Nursing Home Hospitalizations

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1723. doi:10.1001/jama.2023.20631

HHS Launches Climate and Health Outlook Portal

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1723-1724. doi:10.1001/jama.2023.20632

Antivirals Might Preserve Insulin in New-Onset Type 1 Diabetes

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1724. doi:10.1001/jama.2023.20633

Bionic Hand Delivers More Control, Less Pain

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1724. doi:10.1001/jama.2023.20634

Donor Immune Cells May Reduce or Eliminate Need for Immunosuppressants

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1724. doi:10.1001/jama.2023.20635

Updated Numbers Show No Progress in Reducing Global Preterm Births

Emily Harris

Abstract Full Text

JAMA. 2023;330(18):1724. doi:10.1001/jama.2023.20636

Poetry and Medicine

Being (the) Patient

Stephi Cham, MA, MT-BC

Abstract Full Text

JAMA. 2023;330(18):1806. doi:10.1001/jama.2023.19773

Editor's Note
What’s in a Name?
Rafael Campo, MD, MA

JAMA

JAMA Revisited

The Menace of “Moonshine” Whisky

Abstract Full Text

JAMA. 2023;330(18):1807. doi:10.1001/jama.2022.16116

JAMA Patient Page

Over-the-Counter Progestin-Only Oral Contraceptives

Erin Fleurant, MD; Mugdha Mokashi, MD, MPH; Melissa A. Simon, MD, MPH

Abstract Full Text

free access has audio

JAMA. 2023;330(18):1810. doi:10.1001/jama.2023.17781

This JAMA Patient Page describes progestin-only oral contraceptive pills, which recently have been approved to be sold over the counter.

Audio: Over-the-Counter Oral Contraceptive Pills

Comment & Response

US Trends in Maternal Mortality by Racial and Ethnic Group

Lydia H. Pecker, MD, MHS; Nansi S. Boghossian, MPH, PhD; George Saade, MD

Abstract Full Text

JAMA. 2023;330(18):1799. doi:10.1001/jama.2023.17544

US Trends in Maternal Mortality by Racial and Ethnic Group

Lauren M. Rossen, PhD, MS; Donna Hoyert, PhD; Amy M. Branum, PhD, MS

Abstract Full Text

JAMA. 2023;330(18):1799-1800. doi:10.1001/jama.2023.17547

US Trends in Maternal Mortality by Racial and Ethnic Group—Reply

Laura G. Fleszar, MPH; Catherine O. Johnson, PhD, MPH; Gregory A. Roth, MD, MPH

Abstract Full Text

JAMA. 2023;330(18):1800-1801. doi:10.1001/jama.2023.17550

Meropenem Administration in Critically Ill Patients With Sepsis

Ali Jabareen, PharmD; Daniel Kurnik, MD

Abstract Full Text

JAMA. 2023;330(18):1801. doi:10.1001/jama.2023.17733

Meropenem Administration in Critically Ill Patients With Sepsis—Reply

Giacomo Monti, MD; Martina Baiardo Redaelli, MD; Alberto Zangrillo, MD

Abstract Full Text

JAMA. 2023;330(18):1801-1802. doi:10.1001/jama.2023.17736

Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis After Kidney Transplant

Matthew B. Roberts, MBBS, MPH; Camille N. Kotton, MD

Abstract Full Text

JAMA. 2023;330(18):1802-1803. doi:10.1001/jama.2023.18022

Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis After Kidney Transplant

Ilies Benotmane, MD, PhD; Peggy Perrin, MD; Sophie Caillard, MD, PhD

Abstract Full Text

JAMA. 2023;330(18):1803. doi:10.1001/jama.2023.18019

Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis After Kidney Transplant—Reply

Ajit P. Limaye, MD; Barbara Haber, MD

Abstract Full Text

JAMA. 2023;330(18):1803-1804. doi:10.1001/jama.2023.18025

Correction

Incorrect Data

Abstract Full Text

free access

JAMA. 2023;330(18):1805. doi:10.1001/jama.2023.19502

Incomplete Reporting of Results

Abstract Full Text

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JAMA. 2023;330(18):1805. doi:10.1001/jama.2023.19501

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November 14, 2023, Vol 330, No. 18, Pages 1715-1810

Caring for the Critically Ill Patient

Recommendation Statement

Evidence Report

AI in Medicine

AI in Medicine

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