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Meta-Analysis
. 2023 Jun 1;177(6):567-581.
doi: 10.1001/jamapediatrics.2023.0846.

Changes in Depression and Anxiety Among Children and Adolescents From Before to During the COVID-19 Pandemic: A Systematic Review and Meta-analysis

Sheri Madigan  1   2 , Nicole Racine  3   4 , Tracy Vaillancourt  3   5 , Daphne J Korczak  6   7 , Jackson M A Hewitt  1   2 , Paolo Pador  1 , Joanne L Park  1   2 , Brae Anne McArthur  1   2 , Celeste Holy  1 , Ross D Neville  8
Affiliations
Meta-Analysis

Changes in Depression and Anxiety Among Children and Adolescents From Before to During the COVID-19 Pandemic: A Systematic Review and Meta-analysis

Sheri Madigan et al. JAMA Pediatr. .

Abstract

Importance: There is a growing body of high-quality cohort-based research that has examined changes in child and adolescent mental health during the COVID-19 pandemic vs before the pandemic. Some studies have found that child and adolescent depression and anxiety symptoms have increased, while others have found these symptoms to have remained stable or decreased.

Objective: To synthesize the available longitudinal cohort-based research evidence to estimate the direction and magnitude of changes in depression and anxiety symptoms in children and adolescents assessed before and during the pandemic.

Data sources: Medline, Embase, and PsycInfo were searched for studies published between January 1, 2020, and May 17, 2022.

Study selection: Included studies reported on depression and/or anxiety symptoms, had cohort data comparing prepandemic to pandemic estimates, included a sample of children and/or adolescents younger than 19 years, and were published in English in a peer-reviewed journal.

Data extraction and synthesis: In total, 53 longitudinal cohort studies from 12 countries with 87 study estimates representing 40 807 children and adolescents were included.

Main outcomes and measures: Standardized mean changes (SMC) in depression and anxiety symptoms from before to during the pandemic.

Results: The analysis included 40 807 children and adolescents represented in pre-COVID-19 studies and 33 682 represented in during-COVID-19 studies. There was good evidence of an increase in depression symptoms (SMC, 0.26; 95% CI, 0.19 to 0.33). Changes in depression symptoms were most conclusive for study estimates among female individuals (SMC, 0.32; 95% CI, 0.21 to 0.42), study estimates with mid to high income (SMC, 0.35; 95% CI, 0.07 to 0.63), and study estimates sourced from North America (SMC, 0.25; 95% CI, 0.15 to 0.36) and Europe (SMC, 0.35; 95% CI, 0.17 to 0.53). There was strong evidence that anxiety symptoms increased slightly during the pandemic (SMC, 0.10; 95% CI, 0.04 to 0.16), and there was some evidence of an increase in study estimates with mid to high income.

Conclusions: This systematic review and meta-analysis of longitudinal studies including children and adolescents found an increase in depression symptoms during the COVID-19 pandemic, particularly among female individuals and those from relatively higher-income backgrounds.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Vaillancourt is the Chair of the COVID-19 Task Force for the Royal Society of Canada. Dr Korczak is the Chair of the Mental Health Task Force of the Canadian Paediatric Society. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Forest Plot of Changes in Depression Symptoms Among Children and Adolescents Surveyed Before and During the COVID-19 Pandemic
Data represent standardized mean changes (SMC). Error bars represent 95% CIs. Gray area represents slight changes (ie, ±0.2 standardized units). The blue diamond represents the overall mean change and corresponding 95% CI.
Figure 2.
Figure 2.. Forest Plot of Changes in Anxiety Symptoms Among Children and Adolescents Surveyed Before and During the COVID-19 Pandemic
Data represent standardized mean changes (SMC). Error bars represent 95% CIs. Gray area represents slight changes (ie, ±0.2 standardized units). The blue diamond represents the overall mean change and corresponding 95% CI.
See this image and copyright information in PMC

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