Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects

doi:10.1038/s41386-022-01424-z

. 2023 Jan;48(1):215-216.

doi: 10.1038/s41386-022-01424-z.

Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects

Katherine M Nautiyal¹, David B Yaden²

Affiliations

¹ Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, 03755, USA. [email protected].
² Department of Psychiatry and Behavioral Sciences, Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

PMID: 35982239
PMCID: PMC9700748
DOI: 10.1038/s41386-022-01424-z

Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects

Katherine M Nautiyal et al. Neuropsychopharmacology. 2023 Jan.

. 2023 Jan;48(1):215-216.

doi: 10.1038/s41386-022-01424-z.

Authors

Katherine M Nautiyal¹, David B Yaden²

Affiliations

¹ Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, 03755, USA. [email protected].
² Department of Psychiatry and Behavioral Sciences, Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

PMID: 35982239
PMCID: PMC9700748
DOI: 10.1038/s41386-022-01424-z

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

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References

1. Vollenweider FX, Preller KH. Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders. Nat Rev Neurosci. 2020;21:611–24. doi: 10.1038/s41583-020-0367-2. - DOI - PubMed
1. Yaden DB, Griffiths RR. The subjective effects of psychedelics are necessary for their enduring therapeutic effects. ACS Pharm Transl Sci. 2021;4:568–72. doi: 10.1021/acsptsci.0c00194. - DOI - PMC - PubMed
1. Olson DE. The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects. ACS Pharm Transl Sci. 2021;4:563–7. doi: 10.1021/acsptsci.0c00192. - DOI - PMC - PubMed
1. Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM, Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci USA. 2021;118:e2022489118. - PMC - PubMed
1. Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, et al. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron. 2021;109:2535–44. doi: 10.1016/j.neuron.2021.06.008. - DOI - PMC - PubMed

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[1] Vollenweider FX, Preller KH. Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders. Nat Rev Neurosci. 2020;21:611–24. doi: 10.1038/s41583-020-0367-2. - DOI - PubMed

[2] Vollenweider FX, Preller KH. Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders. Nat Rev Neurosci. 2020;21:611–24. doi: 10.1038/s41583-020-0367-2. - DOI - PubMed

[3] Yaden DB, Griffiths RR. The subjective effects of psychedelics are necessary for their enduring therapeutic effects. ACS Pharm Transl Sci. 2021;4:568–72. doi: 10.1021/acsptsci.0c00194. - DOI - PMC - PubMed

[4] Yaden DB, Griffiths RR. The subjective effects of psychedelics are necessary for their enduring therapeutic effects. ACS Pharm Transl Sci. 2021;4:568–72. doi: 10.1021/acsptsci.0c00194. - DOI - PMC - PubMed

[5] Olson DE. The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects. ACS Pharm Transl Sci. 2021;4:563–7. doi: 10.1021/acsptsci.0c00192. - DOI - PMC - PubMed

[6] Olson DE. The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects. ACS Pharm Transl Sci. 2021;4:563–7. doi: 10.1021/acsptsci.0c00192. - DOI - PMC - PubMed

[7] Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM, Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci USA. 2021;118:e2022489118. - PMC - PubMed

[8] Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM, Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci USA. 2021;118:e2022489118. - PMC - PubMed

[9] Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, et al. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron. 2021;109:2535–44. doi: 10.1016/j.neuron.2021.06.008. - DOI - PMC - PubMed

[10] Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, et al. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron. 2021;109:2535–44. doi: 10.1016/j.neuron.2021.06.008. - DOI - PMC - PubMed

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Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects

Affiliations

Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects

Authors

Affiliations

Conflict of interest statement

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Grants and funding

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