Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial
- PMID: 26256137
- DOI: 10.1016/j.ctcp.2015.06.003
Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial
Abstract
Objective: To assess the efficacy and safety of topical Matricaria chamomilla (Chamomile) oil in patients with knee osteoarthritis.
Method: Patients were randomized and treated with topical chamomile oil, diclofenac or placebo, 3 times/day for 3 weeks. They were allowed to use acetaminophen as analgesic. The patients were asked about their total acetaminophen use. Moreover, they were assessed in the terms of pain, physical function and stiffness by using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire at the enrolling and weekly.
Results: Chamomile oil significantly reduced the patients' need for acetaminophen (P = 0.001) compared with diclofenac and placebo. However, there were no significant differences in WOMAC questionnaire domains. The patients did not report any adverse events by using chamomile oil.
Conclusion: Chamomile oil decreased the analgesic demand of patients with knee osteoarthritis. In addition, it may show some beneficial effects on physical function, and stiffness of the patients.
Keywords: Chamomile oil; Herbal medicine; Matricaria chamomilla; Osteoarthritis; Phytotherapy; Traditional Persian Medicine.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Comment in
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Chronische Schmerzen – ein leidiges Problem.Forsch Komplementmed. 2016;23(1):6-11. doi: 10.1159/000444552. Epub 2016 Mar 4. Forsch Komplementmed. 2016. PMID: 26977601 German. No abstract available.
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