A systematic review on the anxiolytic effects of aromatherapy on rodents under experimentally induced anxiety models
- PMID: 20614803
A systematic review on the anxiolytic effects of aromatherapy on rodents under experimentally induced anxiety models
Abstract
Purpose: We reviewed studies from 1999 to 2009 on anxiolytic effects of different essential oils toward rodents in anxiety-related behavioral models.
Method: Journal papers that evaluated the anxiolytic effects of essential oils for rodents were extracted from available electronic data bases.
Results: The results based on 14 studies showed that different rodent species were recruited including ICR mice and Swiss mice. Most of studies applied the Elevated Plus Maze (EPM) as the animal behavioral model. Lavender oil was the most popular within the 14 studies. Lavender and rose oils were found to be effective in some of the studies. Only one study reported the underlying neurophysiological mechanism in terms of concentrations of emotionally related neuro-transmitters such as dopamine, serotonin, and their derivatives, in various brain regions.
Conclusion: Some essential oils are found to be effective to induce anxiolytic effect in rodents under different animal anxiety models. However, more standardized experimental procedures and outcome measures are needed in future studies. Translational research to human subjects is also recommended.
Similar articles
-
How Strong is the Evidence for the Anxiolytic Efficacy of Lavender?: Systematic Review and Meta-analysis of Randomized Controlled Trials.Asian Nurs Res (Korean Soc Nurs Sci). 2019 Dec;13(5):295-305. doi: 10.1016/j.anr.2019.11.003. Epub 2019 Nov 16. Asian Nurs Res (Korean Soc Nurs Sci). 2019. PMID: 31743795
-
Effectiveness of Silexan oral lavender essential oil compared to inhaled lavender essential oil aromatherapy for sleep in adults: a systematic review.JBI Database System Rev Implement Rep. 2018 Nov;16(11):2109-2117. doi: 10.11124/JBISRIR-2017-003823. JBI Database System Rev Implement Rep. 2018. PMID: 30439747
-
A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models.Molecules. 2015 Oct 14;20(10):18620-60. doi: 10.3390/molecules201018620. Molecules. 2015. PMID: 26473822 Free PMC article. Review.
-
Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.J Ethnopharmacol. 2013 May 20;147(2):412-8. doi: 10.1016/j.jep.2013.03.028. Epub 2013 Mar 22. J Ethnopharmacol. 2013. PMID: 23524167
-
A systematic review on the anxiolytic effects of aromatherapy in people with anxiety symptoms.J Altern Complement Med. 2011 Feb;17(2):101-8. doi: 10.1089/acm.2009.0277. Epub 2011 Feb 10. J Altern Complement Med. 2011. PMID: 21309711 Review.
Cited by
-
Housing and Environmental Enrichment of the Domestic Ferret: A Multi-Sector Survey.Animals (Basel). 2022 Apr 20;12(9):1065. doi: 10.3390/ani12091065. Animals (Basel). 2022. PMID: 35565492 Free PMC article.
-
Inhalation Aromatherapy via Brain-Targeted Nasal Delivery: Natural Volatiles or Essential Oils on Mood Disorders.Front Pharmacol. 2022 Apr 12;13:860043. doi: 10.3389/fphar.2022.860043. eCollection 2022. Front Pharmacol. 2022. PMID: 35496310 Free PMC article. Review.
-
Essential Oils and Their Constituents Targeting the GABAergic System and Sodium Channels as Treatment of Neurological Diseases.Molecules. 2018 May 2;23(5):1061. doi: 10.3390/molecules23051061. Molecules. 2018. PMID: 29724056 Free PMC article. Review.
-
Exploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System Targets.Front Pharmacol. 2017 May 19;8:280. doi: 10.3389/fphar.2017.00280. eCollection 2017. Front Pharmacol. 2017. PMID: 28579958 Free PMC article.
-
Anxiolytic effect of essential oils of Salvia miltiorrhiza in rats.Int J Clin Exp Med. 2015 Aug 15;8(8):12756-64. eCollection 2015. Int J Clin Exp Med. 2015. PMID: 26550189 Free PMC article.