Comparative study on the in vitro human skin permeation of monoterpenes and phenylpropanoids applied in rose oil and in form of neat single compounds
- PMID: 20225652
Comparative study on the in vitro human skin permeation of monoterpenes and phenylpropanoids applied in rose oil and in form of neat single compounds
Abstract
Essential oils are ingredients of cosmetic and health care products as well as massage oil used in aromatherapy. There is no doubt that essential oils and their components are able to permeate human skin. But information is rare dealing with percutanous absorption of essential oils in more detail. In this paper we investigated the in vitro skin permeation of monoterpenes and phenylpropanoids applied in pure rose oil and in form of neat single substances. We found that the application form had an exceeding influence on the skin permeation behaviour of the compounds. For substances applied in rose oil a clear relationship between their lipophilic character, chemical structure, and skin permeation could be confirmed. Regarding the P(app)-values the substances are ranked in the order: monoterpene hydrocarbons < monoterpene alcohols < monoterpene ketons < phenylpropanoids. In contrast, for neat single substances there were no relationships between their lipophilic characters, structures and skin permeation. Furthermore, except for alpha-pinene and isomenthone, the P(app)-values of all other substances were several times higher when applied in pure native rose oil than in their neat form. This suggests that co-operative interactions between essential oil components may promote skin permeation behaviour of essential oil and its components.
Similar articles
-
Variation of in vitro human skin permeation of rose oil between different application sites.Forsch Komplementmed. 2010;17(3):126-31. doi: 10.1159/000315043. Epub 2010 Jun 14. Forsch Komplementmed. 2010. PMID: 20616515
-
Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors.Int Rev Neurobiol. 2009;85:237-48. doi: 10.1016/S0074-7742(09)85018-6. Int Rev Neurobiol. 2009. PMID: 19607974 Review.
-
Cooperative interaction of monoterpenes and phenylpropanoids on the in vitro human skin permeation of complex composed essential oils.Planta Med. 2009 Oct;75(13):1381-5. doi: 10.1055/s-0029-1185744. Epub 2009 Jun 8. Planta Med. 2009. PMID: 19507114
-
In vitro studies on release and human skin permeation of Australian tea tree oil (TTO) from topical formulations.Eur J Pharm Biopharm. 2006 Oct;64(2):222-8. doi: 10.1016/j.ejpb.2006.05.006. Epub 2006 May 23. Eur J Pharm Biopharm. 2006. PMID: 16846726
-
Toxicity of melaleuca oil and related essential oils applied topically on dogs and cats.Vet Hum Toxicol. 1994 Apr;36(2):139-42. Vet Hum Toxicol. 1994. PMID: 8197716 Review.
Cited by
-
Preparation, Physicochemical Characterization, and Stability Study of Lippia origanoides Essential Oil-based Nanoemulsion as a Topical Delivery System.Pharm Nanotechnol. 2024;12(3):251-261. doi: 10.2174/2211738511666230815155614. Pharm Nanotechnol. 2024. PMID: 37581527
-
Evaluating the Skin Interactions and Permeation of Alginate/Fucoidan Hydrogels Per Se and Associated with Different Essential Oils.Pharmaceutics. 2023 Jan 5;15(1):190. doi: 10.3390/pharmaceutics15010190. Pharmaceutics. 2023. PMID: 36678818 Free PMC article.
-
Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being.Front Pharmacol. 2022 Aug 24;13:956541. doi: 10.3389/fphar.2022.956541. eCollection 2022. Front Pharmacol. 2022. PMID: 36091825 Free PMC article. Review.
-
The Effect of Cream and Gel Vehicles on the Percutaneous Absorption and Skin Retention of a New Eugenol Derivative With Antioxidant Activity.Front Pharmacol. 2021 Jun 25;12:658381. doi: 10.3389/fphar.2021.658381. eCollection 2021. Front Pharmacol. 2021. PMID: 34248621 Free PMC article.
-
Antioxidant and Cytoprotective Potential of the Essential Oil Pistacia lentiscus var. chia and Its Major Components Myrcene and α-Pinene.Antioxidants (Basel). 2021 Jan 18;10(1):127. doi: 10.3390/antiox10010127. Antioxidants (Basel). 2021. PMID: 33477450 Free PMC article.