Functional brain changes in presymptomatic Huntington's disease
- PMID: 15174024
- DOI: 10.1002/ana.20121
Functional brain changes in presymptomatic Huntington's disease
Abstract
Evidence suggests early structural brain changes in individuals with the Huntington's disease (HD) genetic mutation who are presymptomatic for the movement symptoms of the illness. The aim of this study was to investigate the presence of functional brain changes in this same population using functional magnetic resonance imaging. Subjects and matched controls underwent an functional magnetic resonance imaging "interference" protocol, a task known to be mediated in part by corticostriatal circuitry. In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls.
Similar articles
-
Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington's disease.Exp Neurol. 2011 Oct;231(2):214-22. doi: 10.1016/j.expneurol.2011.06.011. Epub 2011 Jun 25. Exp Neurol. 2011. PMID: 21726553
-
Prefrontal cortex volume reduction on MRI in preclinical Huntington's disease relates to visuomotor performance and CAG number.Parkinsonism Relat Disord. 2009 Mar;15(3):213-9. doi: 10.1016/j.parkreldis.2008.05.010. Epub 2008 Jul 15. Parkinsonism Relat Disord. 2009. PMID: 18632301
-
[Functional imaging of cognitive processes in Huntington's disease and its presymptomatic mutation carriers].Nervenarzt. 2008 Apr;79(4):408-20. doi: 10.1007/s00115-007-2390-1. Nervenarzt. 2008. PMID: 18074113 Review. German.
-
Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI.Brain. 2007 Nov;130(Pt 11):2845-57. doi: 10.1093/brain/awm210. Epub 2007 Sep 13. Brain. 2007. PMID: 17855375
-
Huntington's disease: pathogenesis, diagnosis and treatment.J Psychiatry Neurosci. 1994 Nov;19(5):359-67. J Psychiatry Neurosci. 1994. PMID: 7528535 Free PMC article. Review.
Cited by
-
Epigenomic Remodeling in Huntington's Disease-Master or Servant?Epigenomes. 2020 Jul 31;4(3):15. doi: 10.3390/epigenomes4030015. Epigenomes. 2020. PMID: 34968288 Free PMC article. Review.
-
Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington's disease (Enroll-HD).J Neurol Neurosurg Psychiatry. 2020 Jun;91(6):622-630. doi: 10.1136/jnnp-2019-322038. Epub 2020 Mar 30. J Neurol Neurosurg Psychiatry. 2020. PMID: 32229581 Free PMC article.
-
Cortical and Striatal Circuits in Huntington's Disease.Front Neurosci. 2020 Feb 6;14:82. doi: 10.3389/fnins.2020.00082. eCollection 2020. Front Neurosci. 2020. PMID: 32116525 Free PMC article. Review.
-
The Role of Hypothalamic Pathology for Non-Motor Features of Huntington's Disease.J Huntingtons Dis. 2019;8(4):375-391. doi: 10.3233/JHD-190372. J Huntingtons Dis. 2019. PMID: 31594240 Free PMC article. Review.
-
Cortical circuit alterations precede motor impairments in Huntington's disease mice.Sci Rep. 2019 Apr 29;9(1):6634. doi: 10.1038/s41598-019-43024-w. Sci Rep. 2019. PMID: 31036840 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical