16 Best Peptide Serums of 2024, Tested by Experts

A winner in GH Beauty Lab's Anti-Aging Serum study — which took place over four weeks — this serum from No7 increased firmness by 21%, improved skin texture and blurred the look of pores. It contains the powerful peptide Matrixyl, in addition to retinol and hydrating hyaluronic acid. Multiple reviewers said that their skin feels smooth and soft after using, with one commenting "by the time I finished the one-ounce bottle, all of the creases almost completely disappeared!" One thing to note: It may not be ideal for sensitive skin. A few reviewers with sensitivities had reactions to the formula.

"This serum is a great option for someone with sensitive skin as it is fragrance-free and helps to hydrate and plump without leaving the skin greasy or feeling irritated," says Dr. Garshick. A previous GH Seal holder, GH Lab Clinical Data evaluations showed that this product hydrates skin significantly up to 24 hours and consumer data indicated that it could leave skin looking and feeling lifted and firmer after one day. A great value, the formula contains peptides to support collagen production and niacinamide to retain moisture and soothe the skin. Be careful when opening; some users reported issues with the dropper working properly.

"Combining peptides, pomegranate seed oil and hyaluronic acid, this serum works to improve the appearance of fine lines and wrinkles while also helping to firm, lift and tighten the skin," says Dr. Garshick. She loves that it doesn't leave skin feeling dry or irritated, as "it also contains squalane to help support the skin barrier and leaves the skin feeling soft and smooth." Reviewers like the light scent but are mixed on the results; some felt that it was super hydrating but didn't do much in terms of wrinkle reduction.

Dr. Garshick recommends this for sagging skin (of all skin types) as it helps to boost collagen and elastin production while remaining gentle on the skin. "It incorporates a blend of 10 peptides, glycerin and antioxidants which help nourish, improve the overall texture and tone and firm the skin," she says. It's gentle enough to use twice daily and is designed for the face, neck and decolletage. FYI: A few reviewers noted that the pump breaks easily.

Gentle enough for all skin types, this GH Seal holder contains a key peptide that helps maintain hyaluronic acid levels to help hydrate and plump skin. It's non-comedogenic, so it won't cause breakouts or clog pores. It is on the pricier side, but the results speak for themselves: After 12 weeks, clinical data showed significant improvement in the appearance of deep wrinkles and 91% of testers agreed they were less visible.

Copper peptides do double duty: They help with collagen production and protect against free radical damage. "This serum uses powerful copper peptides, along with a blend of other peptides, amino acids and hyaluronic acid to fight fine lines and wrinkles and improve overall elasticity," says Dr. Garshick. Plus, it's moisturizing and brightening. A few reviewers did notice some skin discoloration after using, so you may want to try a test patch before using all over.

A true glow getter, "Alphascience's Alpha Bright Serum contains acetyl glycyl beta-alanine, a skin lightening peptide that acts to block the enzyme needed for pigment production in the skin and prevents pigment from moving to the upper layers of the skin and becoming visible," says Dr. Mraz. Meaning, it helps even skin tone for an overall brighter complexion. It also has antioxidants, including ginkgo biloba, which gives the formula a unique scent that may not be for everyone.

Isdin’s silky serum delivers results fast and furiously. The Good Housekeeping Beauty Award Winner contains two types of hyaluronic acid and peptides to plump both inner and outer layers of skin. GH Beauty Lab data evaluations found that the formulation delivers immediate plumping and smoothing effects and will improve skin’s texture over time. “I love how this serum soaks in quickly and smooths my face instantly” and “it left my skin refreshed,” two testers said.

"Thanks to a combination of five potent peptides and a precise applicator, this serum helps to reduce the appearance of expression lines and wrinkles, especially around the eyes," says Dr. Garshick. The GH Beauty Award winner also incorporates hyaluronic acid that helps to plump the skin and reduce dryness. The stainless steel tip allows for targeted (and cooling) application, although some reviewers reported issues with it dispensing product improperly.

A favorite of Wnek's, Estēe Lauder's classic serum is popular (over 22,000 reviews!) for good reason: "I love it because it feels gentle on my combination/oily skin and yet makes my skin feel and look smoother and firmer," she says. The luxe formula contains hyaluronic acid, antioxidants and the brand's proprietary "night peptide" which work synergistically to plump, firm and reduce the appearance of fine lines. While most reviewers rave over the results, a few noted breakouts and irritation from the serum.

"A blend of hyaluronic acid, polyglutamic acid and squalane plumps and boosts moisture levels in the skin, while copper peptides help to increase collagen production," says Dr. Garshick. The lightweight (and blue-tinted, thanks to the copper) formula absorbs instantly and leaves skin soft and smooth. Make sure to keep the bottle tightly closed as a few reviewers reported leaking.

The name says it all: This twice daily serum improves the overall appearance of fine lines and wrinkles without any injectables. "It contains a blend of peptides, including copper peptides, ceramides, niacinamide and hyaluronic acid to plump and firm skin, while also strengthening the skin’s natural moisture barrier," says Dr. Garshick. Be mindful when applying because some reviewers felt the formula was very liquid-y and came out of the dropper quickly.

GH Beauty Director April Franzino loves that this peptide serum is super gentle on her skin, unlike some anti-aging products that can be harsh. She was thrilled with the results as well: "It gave a noticeable plumping, hydrated effect." Reviewers who have both acne-prone and sensitive skin agree and felt that it left skin plump, firm and smooth, with no irritation. It does have a thicker texture which some say can feel oily on skin.

Like a drink of water for your skin, Rhode's glazing fluid contains a hydrating combination of niacinamide, peptides, hyaluronic acid and marula oil. "It leaves my skin soft and smooth," says GH Beauty Assistant Catharine Malzahn. "I like to apply this gel-like serum after cleansing and before moisturizer — I’ve worn it under makeup without any issues." One thing to note: some reviewers complained about the "chemical-y" smell.

A major bargain at just $12, GH Food Producer Tina Martinez received a recommendation from a dermatologist for this peptide serum and thought it may be too good to be true. "I have been using it for the last month and I feel there is a noticeable difference in my skin and other people have noticed as well," she says. "I use it nightly before bed and my skin feels more hydrated and healthy." Many Amazon reviewers agree with this moisturizing effect, although some didn't see much change in their skin after using.

If fine lines are your focus, look no further. "Medik8's Liquid Peptides serum is packed with 10 different peptides, including matrixyl 3000, copper peptides, an expression line peptide and carnosine to help firm skin and soften the appearance of fine lines and wrinkles," says Dr. Garshick. It also contains hyaluronic acid to moisturize and plump. Beware of bottle malfunctions; a few reviewers struggled with getting it open.