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Editorial
. 2023 Oct 19:12:e92714.
doi: 10.7554/eLife.92714.

When diet meets genetics

Karthickeyan Chella Krishnan  1
Affiliations
Editorial

When diet meets genetics

Karthickeyan Chella Krishnan. Elife. .

Abstract

Gene expression profiling of a diverse mouse population helps to decipher how a fat-rich diet contributes to inflammatory bowel disease.

Keywords: BXD mice; colon; computational biology; gut health; human; mouse; systems biology; systems genetics; uk biobank.

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Conflict of interest statement

KC No competing interests declared

Figures

Figure 1.
Figure 1.. A systems genetics approach to identifying genes involved in diet-related gut inflammation.
A diverse group of 52 BXD mouse strains were exposed to regular (chow) or fat-rich diets. Their guts were then collected and gene expression was measured. Further network modeling analyses revealed that the fat-rich diet led to gut inflammation gene expression profiles similar to those in existing, published mouse and human IBD datasets and identified two modules of interest (Modules A and D). Within module D, two genes (Muc4 and Epha6) were identified as candidates that may control gut inflammation in IBD as their genetic variants were also associated with ulcerative colitis in humans. IBD, Inflammatory Bowel Disease.
See this image and copyright information in PMC

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