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Review
. 2022 Apr;74(4):377-384.
doi: 10.11477/mf.1416202048.

[Mechanisms of Fear Memory Processes]

[Article in Japanese]
Satoshi Kida  1
Affiliations
Review

[Mechanisms of Fear Memory Processes]

[Article in Japanese]
Satoshi Kida. Brain Nerve. 2022 Apr.

Abstract

Fear memory is defined as the associative (fear-conditioned) memory between the context of a fear experience (conditioned stimulus) and fear itself (unconditioned stimulus). Re-exposure to the conditioned context retrieves the fear memory and triggers a fear response. Fear memories have been observed in both nematodes and humans, suggesting common neural mechanisms. Studies using rodents and other animal models have identified the mechanisms of fear memory processes, such as consolidation, retrieval, reconsolidation, destabilization, and extinction, at the molecular, cellular, circuit, and behavioral levels. This review introduces fear memory processes and their mechanisms.

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