Relevance of physical function in the association of red and processed meat intake with all-cause, cardiovascular, and cancer mortality
- PMID: 31377183
- DOI: 10.1016/j.numecd.2019.06.019
Relevance of physical function in the association of red and processed meat intake with all-cause, cardiovascular, and cancer mortality
Abstract
Background and aims: Intake of red and processed meat has been associated with a higher risk of morbidity and mortality; it is unknown whether these associations are modified by overall physical health. This study examined the associations of red and processed meat consumption with all-cause, cardiovascular, and cancer mortality and investigated whether markers of physical function modified the associations.
Methods and results: This observational cohort study used UK Biobank data derived from 419,075 participants free from cancer and cardiovascular disease. Cox models assessed the association of red and processed meat consumption (obtained from a baseline food frequency questionnaire) with mortality, adjusted for potential confounders. Objectively measured handgrip strength and self-reported walking pace were used as interaction terms. The median age was 57 (interquartile range, 49-63) years and 54.9% were women. Over 7 years of follow-up, 8586 all-cause, 1660 cardiovascular, and 4812 cancer deaths occurred. Each additional serving per week of red and processed meat was associated with a hazard ratio (HR) of 1.037 (95% CI: 1.028-1.047) for all-cause; 1.030 (1.009-1.051) for cardiovascular; and 1.029 (1.016-1.042) for cancer mortality. The association of red and processed meat consumption was modified by walking pace, with brisk walkers having the lowest risk per additional serving for all-cause and cancer mortality (HR 1.025; 1.006-1.045 and 1.015; 0.990-1.040, respectively); no interaction was observed for handgrip strength.
Conclusion: The known risk of mortality associated with red and processed meat consumption may be lower in those with high physical function.
Keywords: Handgrip strength; Mortality; Processed meat; Red meat; Walking pace.
Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Similar articles
-
How to Keep the Balance between Red and Processed Meat Intake and Physical Activity Regarding Mortality: A Dose-Response Meta-Analysis.Nutrients. 2023 Jul 29;15(15):3373. doi: 10.3390/nu15153373. Nutrients. 2023. PMID: 37571311 Free PMC article. Review.
-
Associations between meat consumption and all-cause and cause-specific mortality in middle-aged and older adults with frailty.J Nutr Health Aging. 2024 Apr;28(4):100191. doi: 10.1016/j.jnha.2024.100191. Epub 2024 Feb 14. J Nutr Health Aging. 2024. PMID: 38359750
-
Associations of Processed Meat, Unprocessed Red Meat, Poultry, or Fish Intake With Incident Cardiovascular Disease and All-Cause Mortality.JAMA Intern Med. 2020 Apr 1;180(4):503-512. doi: 10.1001/jamainternmed.2019.6969. JAMA Intern Med. 2020. PMID: 32011623 Free PMC article.
-
Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality: a UK Biobank observational study.Eur Heart J. 2017 Nov 14;38(43):3232-3240. doi: 10.1093/eurheartj/ehx449. Eur Heart J. 2017. PMID: 29020281 Free PMC article.
-
Red and processed meat consumption and mortality: dose-response meta-analysis of prospective cohort studies.Public Health Nutr. 2016 Apr;19(5):893-905. doi: 10.1017/S1368980015002062. Epub 2015 Jul 6. Public Health Nutr. 2016. PMID: 26143683 Free PMC article. Review.
Cited by
-
How to Keep the Balance between Red and Processed Meat Intake and Physical Activity Regarding Mortality: A Dose-Response Meta-Analysis.Nutrients. 2023 Jul 29;15(15):3373. doi: 10.3390/nu15153373. Nutrients. 2023. PMID: 37571311 Free PMC article. Review.
-
Cardiovascular Harm From Egg Yolk and Meat: More Than Just Cholesterol and Saturated Fat.J Am Heart Assoc. 2021 Apr 6;10(7):e017066. doi: 10.1161/JAHA.120.017066. Epub 2021 Mar 15. J Am Heart Assoc. 2021. PMID: 33719494 Free PMC article. No abstract available.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical