Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec 27;18(1):702.
doi: 10.1186/s12879-018-3617-4.

A suppurative thyroiditis and perineal subcutaneous abscess related with aspergillus fumigatus: a case report and literature review

Jiaying Tan  1 , Jun Shen  1 , Yong Fang  1 , Liping Zhu  2 , Yang Liu  3 , Ye Gong  1 , Hechen Zhu  1 , Zupeng Hu  1 , Gang Wu  4
Affiliations
Review

A suppurative thyroiditis and perineal subcutaneous abscess related with aspergillus fumigatus: a case report and literature review

Jiaying Tan et al. BMC Infect Dis. .

Abstract

Background: Invasive aspergillosis is a complication in immunocompromised patients and commonly detected in patients with hematological malignancies, which mostly affect the lungs. Because of its high iodine content, rich blood supply and capsule, the thyroid is considered to be less prone to microbial invasion thus most infectious thyroiditis cases are caused by bacteria. However, a few case reports have described thyroid gland aspergilloses, most of which were due to disseminated invasive aspergillosis.

Case presentation: We first report a case of thyroid gland and subcutaneous labium majus aspergillosis in a Chinese patient who received long-term glucocorticoid treatment for systemic lupus erythematosus (SLE) and lupus nephritis, and then we reviewed 36 articles describing similar aspergillus infections in 41 patients.

Conclusion: We included 29 cases of diagnosed aspergillus thyroiditis and analyzed clinical findings, treatments and outcomes to provide clinical information for diagnosis and prognosis of thyroiditis caused by Aspergillus fumigatus.

Keywords: Aspergillus fumigatus; Aspergillus thyroiditis; Caspofungin; Diagnosis; Systemic lupus erythematosus; Voriconazole.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written consent for publication was obtained from the patient.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Chest computed tomography showed the bilateral patches in the lungs of the patient as opacities in the middle and lower lobes, multiple shadows of fibrotic streaks, high-density nodules, and mediastinal calcification of lymph nodes
Fig. 2
Fig. 2
Neck computed tomography revealed effective drainage of the left lobe of the thyroid gland while abscesses remained in the right lobe
Fig. 3
Fig. 3
The web search results of publications about aspergillus thyroiditis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Barchiesi F, Mazzocato S, Mazzanti S, Gesuita R, Skrami E, Fiorentini A, Singh N. Invasive aspergillosis in liver transplant recipients: epidemiology, clinical characteristics, treatment, and outcomes in 116 cases. Liver Transpl. 2015;21(2):204–212. doi: 10.1002/lt.24032. - DOI - PubMed
    1. Denning DW. Therapeutic outcome in invasive aspergillosis. Clin Infect Dis. 1996;23(3):608–615. doi: 10.1093/clinids/23.3.608. - DOI - PubMed
    1. Vogeser M, Haas A, Ruckdeschel G, von Scheidt W. Steroid-induced invasive aspergillosis with thyroid gland abscess and positive blood cultures. Eur J Clin Microbiol Infect Dis. 1998;17(3):215–216. doi: 10.1007/BF01691124. - DOI - PubMed
    1. Bartlett JG. Aspergillosis update. Medicine. 2000;79(4):281–282. doi: 10.1097/00005792-200007000-00009. - DOI - PubMed
    1. Nguyen J, Manera R, Minutti C. Aspergillus thyroiditis: a review of the literature to highlight clinical challenges. Eur J Clin Microbiol Infect Dis. 2012;31(12):3259–3264. doi: 10.1007/s10096-012-1704-9. - DOI - PubMed

MeSH terms