Vitamin K and osteoporosis: Myth or reality?
- PMID: 28403946
- DOI: 10.1016/j.metabol.2017.01.032
Vitamin K and osteoporosis: Myth or reality?
Abstract
Vitamin K is a liposoluble vitamin. The predominant dietary form, phylloquinone or vitamin K1, is found in plants and green vegetables; whereas menaquinone, or vitamin K2, is endogenously synthesized by intestinal bacteria and includes several subtypes that differ in side chain length. Aside from its established role in blood clotting, several studies now support a critical function of vitamin K in improving bone health. Vitamin K is in fact required for osteocalcin carboxylation that in turn regulates bone mineral accretion; it seems to promote the transition of osteoblasts to osteocytes and also limits the process of osteoclastogenesis. Several observational and interventional studies have examined the relationship between vitamin K and bone metabolism, but findings are conflicting and unclear. This systematic review aims to investigate the impact of vitamin K (plasma levels, dietary intake, and oral supplementation) on bone health with a particular interest in bone remodeling, mineral density and fragility fractures.
Keywords: BMD; Fracture; Osteoporosis; Vitamin K1; Vitamin K2.
Copyright © 2017 Elsevier Inc. All rights reserved.
Similar articles
-
Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences.Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970. doi: 10.1080/10408398.2016.1211616. Crit Rev Food Sci Nutr. 2017. PMID: 27437760 Review.
-
Vitamin K and bone health.J Clin Densitom. 2013 Oct-Dec;16(4):409-13. doi: 10.1016/j.jocd.2013.08.017. Epub 2013 Oct 3. J Clin Densitom. 2013. PMID: 24090644 Review.
-
[Serum vitamin K concentration and nutrition].Clin Calcium. 2007 Nov;17(11):1717-26. Clin Calcium. 2007. PMID: 17982192 Review. Japanese.
-
Bone health and osteoporosis: the role of vitamin K and potential antagonism by anticoagulants.Nutr Clin Pract. 2007 Oct;22(5):517-44. doi: 10.1177/0115426507022005517. Nutr Clin Pract. 2007. PMID: 17906277 Review.
-
Effects of vitamin K on calcium and bone metabolism.Curr Opin Clin Nutr Metab Care. 2001 Nov;4(6):483-7. doi: 10.1097/00075197-200111000-00003. Curr Opin Clin Nutr Metab Care. 2001. PMID: 11706280 Review.
Cited by
-
The mediation effect of vitamin A and vitamin D supplement in the association between serum vitamin K levels and musculoskeletal disorders in preschool children.Front Nutr. 2023 Dec 22;10:1239954. doi: 10.3389/fnut.2023.1239954. eCollection 2023. Front Nutr. 2023. PMID: 38188876 Free PMC article.
-
Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity.Int J Mol Sci. 2023 Dec 1;24(23):17038. doi: 10.3390/ijms242317038. Int J Mol Sci. 2023. PMID: 38069361 Free PMC article. Review.
-
The effect of pharmacological treatment in combination with vitamin K on healing in an experimental rat model of osteoporosis.Jt Dis Relat Surg. 2023 Apr 27;34(2):356-364. doi: 10.52312/jdrs.2023.911. Jt Dis Relat Surg. 2023. PMID: 37462639 Free PMC article.
-
Vitamin D, a steroid hormone, from theory to practice.Physiol Res. 2023 Apr 30;72(2):131-136. doi: 10.33549/physiolres.935070. Physiol Res. 2023. PMID: 37159848 Free PMC article.
-
Hypoxia Pathway in Osteoporosis: Laboratory Data for Clinical Prospects.Int J Environ Res Public Health. 2023 Feb 10;20(4):3129. doi: 10.3390/ijerph20043129. Int J Environ Res Public Health. 2023. PMID: 36833823 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
