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. 2015 Sep 15;8(9):16978-83.
eCollection 2015.

Association between whole grain intake and stroke risk: evidence from a meta-analysis

Liqun Fang  1 , Wen Li  2 , Wenjie Zhang  1 , Yanan Wang  1 , Songbin Fu  1
Affiliations

Association between whole grain intake and stroke risk: evidence from a meta-analysis

Liqun Fang et al. Int J Clin Exp Med. .

Abstract

Background: Researches of the relationships between dietary whole grains intake and risk of stroke have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence from observed studies regarding the association between whole grain intake and stroke risk.

Methods: Pertinent studies were identified by searching Web of Knowledge and PubMed up to May 2015. Random-effect model was used to combine the relative risk (RR) with the corresponding 95% confidence intervals (CI). Publication bias was estimated using Egger's regression asymmetry test.

Results: Six prospective studies involving 1635 stroke cases and 247487 participants were included in this meta-analysis. Pooled results suggested that highest category of whole grain intake versus lowest category was significantly associated with reduced the risk of stroke [summary RR = 0.86, 95% CI = 0.73-0.99, I2 = 0.0%]. Inverse associations were also found in the America population [summary RR = 0.81, 95% CI = 0.67-0.98, I(2) = 0.0%] and subgroup analysis of females [summary RR = 0.78, 95% CI = 0.63-0.97, I(2) = 0.0%]. No publication bias was found.

Conclusion: Our analysis indicated that higher whole grain intake has a protective effect on stroke.

Keywords: Whole grain; meta-analysis; stroke.

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Figures

Figure 1
Figure 1
The detailed steps of our literature search.
Figure 2
Figure 2
The forest plot between highest versus lowest categories of whole grain intake and stroke risk.
Figure 3
Figure 3
Analysis of influence of individual study on the association between whole grain intake and stroke risk. Open circle, the pooled RR, given named study is omitted. Horizontal lines represent the 95% CIs.
See this image and copyright information in PMC

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