Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2007 Apr;33(4):726-9.
doi: 10.1007/s00134-007-0534-1. Epub 2007 Feb 9.

A randomized trial of catheter change and short course of antibiotics for asymptomatic bacteriuria in catheterized ICU patients

Marc Leone  1 , Anne-Sophie Perrin, Isabelle Granier, Pierre Visintini, Valery Blasco, François Antonini, Jacques Albanèse, Claude Martin
Affiliations
Randomized Controlled Trial

A randomized trial of catheter change and short course of antibiotics for asymptomatic bacteriuria in catheterized ICU patients

Marc Leone et al. Intensive Care Med. 2007 Apr.

Abstract

Objective: To determine the effect on the occurrence of urosepsis of a treatment with a short course of antibiotics and indwelling urethral catheter replacement in clinically asymptomatic intensive care unit (ICU) patients with a positive urine culture occurring at least 48 h after catheterization.

Methods: A prospective randomized clinical trial was conducted in the medico-surgical ICU of a tertiary care centre. Sixty patients hospitalized in the ICU with an indwelling urethral catheter for longer than 48 h developing an asymptomatic positive urine culture were randomized to receive either a 3-day course of antibiotics associated with the replacement of the indwelling urethral catheter 4 h after first antibiotic administration or no antibiotics, no catheter replacement (standard of care).

Results: Three patients in each group developed urosepsis (P=0.1). There were no significant differences in duration of mechanical ventilation between the study group and the standard of care group (9 [4-20] days vs 5 [2-15] days, P=0.2), in duration of urinary catheterization (22 [11-40] days vs 18 [14-33] days, P=0.8), or in length of ICU stay (28 [13-46] vs 19 [15-34], P=0.6). The recurrence of positive urine culture at days 7 and 15 was not affected by the randomization (P=0.1). The profile of bacterial resistance was similar in the two groups.

Conclusions: Treating a positive urine culture in an asymptomatic patient with an indwelling urethral catheter does not reduce the occurrence of urosepsis in the medico-surgical ICU.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chest. 2001 Jul;120(1):220-4 - PubMed
    1. Crit Care Med. 2003 Apr;31(4):1250-6 - PubMed
    1. Microbes Infect. 2004 Sep;6(11):1026-32 - PubMed
    1. Am J Infect Control. 1988 Jun;16(3):128-40 - PubMed
    1. Ann Intern Med. 1994 May 15;120(10):827-33 - PubMed

Publication types

Substances

LinkOut - more resources