NCBI Announce - Recent Updates

NCBI Updates: Primer-BLAST, dbGaP, and More!

Fri, 28 Jun 2024 09:00:53 -0500

The Latest NCBI Updates

A Modern ClinicalTrials.gov Website

Have you seen our new look? Learn about the modernized ClinicalTrials.gov and improvements such as a streamlined design and optimization for mobile devices, in the latest NCBI Insights Blog.

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NCBI Collaborates with Africa CDC for Data Curation Workshop

Exciting update! We recently collaborated with Africa CDC for a highly successful and first ever data curation workshop in Addis Ababa, training participants from 20 Member States, and it was a great success.

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New Publication: Biomedical Data Repository Concepts and Management Principles

New publication in Nature co-authored by NCBI’s Acting Director, Dr. Kim Pruitt with others at NIH! The publication supports new federal data management and sharing policies for NIH-funded research.

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Now Available! Download Primer-BLAST Results

Need a way to save your Primer-BLAST results? Now you can download them in text, csv, or tsv format for record keeping and/or sending out to order your synthesized nucleotides.

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New dbGaP Tutorial Video!

New video series on the dbGaP submission process now available on our YouTube channel! Check out Part 1 on registering your study.

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NCBI Updates: ClinVar, PubChem, and More!

Fri, 21 Jun 2024 09:01:17 -0500

The Latest NCBI Updates

Important Update for ClinVar Submitters

Attention ClinVar data submitters! The ClinVar submission API now accepts somatic variants classified for clinical impact and oncogenicity.

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New Publication: PubChem Synonym Filtering Process Using Crowdsourcing

New NCBI article in PMC! Learn how the PubChem team improves the quality of chemical name/structure associations through crowdsourcing.

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PubMed Update: Related Citation Links in Search Results

The comment correction type in PubMed search results now include a link to the related citation. Learn more in the NLM Technical Bulletin.

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Study Record Information Displays in the Modernized ClinicalTrials.gov

ClinicalTrials.gov data elements and their requirements have changed as trial reporting laws and policies have evolved. Read the NLM Technical Bulletin to learn how study record information is displayed in the modernized ClinicalTrials.gov website.

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GenBank Release 261.0 is Available!

GenBank release 261.0 (6/18/2024) is now available on the NCBI FTP site. This release has 32.04 trillion bases and 4.51 billion records.

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NCBI Updates: dbSNP, ClinVar, and More!

Fri, 14 Jun 2024 09:30:18 -0500

The Latest NCBI Updates

Use dbSNP to Access Information on Common and Rare Genetic Variants

Did you know that, despite its name, dbSNP includes nearly 1.1 billion human RefSNPs, including microsatellites, small-scale insertions and deletions, and single nucleotide variations for both common variations and clinical mutations?

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Resistance is Futile: A Codeathon to Combat Antimicrobial Resistance

If you perform antimicrobial resistance (AMR) research, check out our upcoming virtual codeathon co-hosted by the National Institute of Allergy and Infectious Diseases (NIAID), which will take place from September 23-27, 2024.

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ClinVar Release Now Available

Now available! Download the latest ClinVar data release today. Get an overview of ClinVar submitted records and additional updates.

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NCBI Updates: ClinicalTrials.gov, Taxonomy, and More!

Fri, 07 Jun 2024 09:30:16 -0500

The Latest NCBI Updates

Marking a Milestone: The Modernized ClinicalTrials.gov Becomes the Singular Website Experience

We’re celebrating a milestone! Learn about the new and improved ClinicalTrials.gov website featuring new efficiencies for finding clinical trials and what you can do to prepare for the retirement of the classic website on June 25, 2024.

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Upcoming Changes to NCBI Taxonomy Classifications

NCBI is continually making improvements to our Taxonomy resource in response to new data and changes in biological nomenclature and classification. In the coming months, we will make several updates.

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New Publication! The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes

Check out our new publication in Nature that compares 6 ape genome assemblies: The complete sequence and comparative analysis of ape sex chromosomes. We annotated the genomes and made them available!

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NCBI at ASM Microbe 2024

Join NCBI in person at the American Society for Microbiology (ASM Microbe) annual meeting, June 13-17, 2024, in Atlanta, GA. We will participate in a variety of activities and events.

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PubMed Update: Wildcard Search Improvements

PubMed search syntax now supports expanded use of the asterisk (*) wildcard character. With this update, wildcards can be used in the middle of a term or phrase, and multiple wildcards can be used in the same term or phrase.

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NCBI Updates: GenBank, dbSNP, and More!

Fri, 31 May 2024 10:00:41 -0500

The Latest NCBI Updates

New Data Available! Access Avian Influenza A (H5N1) Virus Sequences at NCBI

Sequence data from the ongoing avian influenza A (H5N1) virus outbreak in cattle are now available through NLM’s NCBI resources NCBI Virus and NCBI Datasets. These data were submitted by the U.S. Department of Agriculture (USDA), the U.S. Centers for Disease Control and Prevention (CDC), and other institutions.

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NCBI & NIAID Join Forces to Co-Host Virtual AMR Codeathon

Do you perform antimicrobial resistance (AMR) research or would you like to join a team to work on microbial and AMR data analysis? NCBI and the National Institute of Allergy and Infectious Diseases (NIAID) are hosting a virtual codeathon to combat antimicrobial resistance, which will take place September 23-27, 2024.

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Explore Population Genetics in dbSNP with NCBI’s Allele Frequency Aggregator (ALFA)

Access to comprehensive and accurate allele frequency data is essential to understanding the impact of genetic variations on human health and disease. You can search the Database of Single Nucleotide Polymorphisms (dbSNP) for allele frequences with ALFA!

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Update to GenBank Qualifier

Reminder! In collaboration with our INSDC partners, we are changing the name of the GenBank qualifier “/country” to “/geo_loc_name” to better represent the diversity of sample collection location types. This change will go into effect starting June 2024.

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Learn How to Use dbSNP

Do you want to enhance your genetic variant analysis skills and learn to use the power of dbSNP Variation Services? Check out our comprehensive tutorials on GitHub! Master variant comparison and grouping today!

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Significant Updates Coming to the NCBI Datasets APIs and Command-Line Tools

Reminder! Effective June 2024, older API and CLI versions of NCBI Datasets will no longer be supported. Install the latest version of the CLI tools and learn how to access the new API (v2alpha).

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NCBI Updates: NCBI Orthologs, CGV, and More!

Fri, 24 May 2024 09:30:19 -0500

The Latest NCBI Updates

International Nucleotide Database Collaboration (INSDC) Introduces Enhanced Website

NCBI, part of the National Library of Medicine, and other Founding Members of the International Nucleotide Database Collaboration (INSDC) have enhanced its website, aiming to broaden INSDC membership and attract diverse new members.

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Ortholog Groups Added for ~ 2 Million Insect Genes

Find evolutionarily related genes across insects and other arthropods on our new Ortholog webpages. NCBI recently released a set of orthologs for approximately 2 million insect genes.

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New Publication About NCBI's Comparative Genome Viewer (CGV)

New NCBI publication in PLOS Biology! Learn about the Comparative Genome Viewer (CGV), NCBI's visualization tool for analysis of whole genome assembly-assembly alignments.

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NLM Webinar: Modernized ClinicalTrials.gov Update

Do you want to learn more about the modernized ClinicalTrials.gov website and its features? Join us for a webinar on June 6 from 1 - 1:45 PM ET to hear an update on the overall modernization effort and an opportunity to ask questions.

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New Data Added to PubChem

Want to learn more about the chemical compounds used in cosmetic products? Data from the Cosmetic Ingredient Review (CIR) have been added to PubChem.

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NCBI Updates: RefSeq, Pebblescout, and More!

Fri, 17 May 2024 10:00:52 -0500

The Latest NCBI Updates

New! RefSeq Release 224

Check out RefSeq release 224, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. This release contains new annotations generated by NCBI’s eukaryotic genome annotation pipeline for 41 additional species.

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Join NCBI at the AGSx Symposium

Want to learn about the NIH Comparative Genomics Resource (CGR) and how you can use our toolkit of data and tools to unlock arthropod research? Join NCBI at the AGSx Virtual Symposium on Tuesday, May 21 at 11 am - 1 pm EST for a virtual webinar.

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New NCBI Publication! Indexing and Searching Petabase-Scale Nucleotide Resources

Check out NCBI's latest publication in Nature Methods to learn more about Pebblescout for efficient search for matches in large sequence databases such as Sequence Read Archive (SRA).

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NCBI Updates: PGAP, SciENcv, and More!

Fri, 10 May 2024 09:01:09 -0500

The Latest NCBI Updates

New! May 2024 Release of Stand-Alone PGAP

We are happy to announce the release of a new version of the stand-alone Prokaryotic Genome Annotation Pipeline (PGAP). This release comes with incremental improvements by expert curators of the Protein Family Model collection that drives the precision of PGAP’s structural and functional annotation.

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Preview of Updated PMC Journal List Now Available

Try out the updated PMC Journal List and let us know what you think! This redesign makes it easier to determine a journal’s status in PMC and reflects other new features based on user feedback. Read our latest NLM Technical Bulletin for more details.

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Join NCBI at the NSF Grants Conference

Calling NSF Grants Conference attendees! Join NCBI's Bart Trawick, PhD, and Sherri Holland-Bailey, MLIS, on Tuesday, June 4, 10:45 am - 12:00 pm ET for the Research.gov and SciENcv Session. NCBI will also have a table, so be sure to stop by to ask questions, provide feedback, or just chat!

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BioEd Summit: Crafting Student-Centric Curricula with NCBI Resources

Deadline extended! Join us at the NIH campus, August 5-9 for an in-person, training event for science educators - an opportunity to collaborate and create a cutting-edge curricular package featuring real-world data from NCBI. Apply by May 12!

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Job Opening: Director of the National Library of Medicine (NLM)

The National Institutes of Health (NIH) has opened the vacancy announcement launching the recruitment for the next Director of the National Library of Medicine (NLM). Exceptional candidates will demonstrate leadership in information science and data innovation.

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Happy Public Service Recognition Week 2024!

NCBI celebrates Public Service Recognition Week! We are grateful for our dedicated employees who work to advance science and health by providing access to biomedical and genomic information. Learn more about our staff and resources.

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NCBI Updates: GenBank, ClinicalTrials.gov, and More!

Fri, 03 May 2024 10:00:57 -0500

The Latest NCBI Updates

All of Us Research Data Now Available in ClinVar

NCBI is helping to make NIH's All of US Research data available to health care providers & researchers. Check out the new data now available in ClinVar.

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GenBank Release 260.0 is Available!

GenBank release 260.0 is now available on the NCBI FTP site. This release includes 31.18 trillion bases and 4.46 billion records. The total number of sequence data files increased by 1,560 with this release.

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NLM Webinar: Modernized ClinicalTrials.gov Update

Want to learn more about the modernized ClinicalTrials.gov website and its features? Join us on June 6 for a webinar to hear about the overall modernization effort and an opportunity to ask questions!

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NCBI Pathogen Detection Presents the Antibiotic Susceptibility Test (AST) Browser

Have you ever wanted to compare antibiotic resistance data and resistance gene calls in bacteria? Now you can! Easily access and browse antibiotic susceptibility testing (AST) data and link to other NCBI resources using the new AST Browser.

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Automated Lineage Definitions Now Available in NCBI Virus SARS-CoV-2 Variants Overview

Recently, NCBI Virus SARS-CoV-2 Variants Overview moved from a manual to an automated process for selecting mutations required to define a lineage. With this update, the SARS-CoV-2 Variant Overview provides coverage for all SARS-CoV-2 lineages and is no longer limited to only lineages with CDC status.

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MTIX: the Next-Generation Algorithm for Automated Indexing of MEDLINE

We are pleased to announce the next major milestone in automated MEDLINE indexing: the implementation of the MTIX (Medical Text Indexer-NeXt Generation) algorithm, which replaces the MTIA (Medical Text Indexer Automated) algorithm.

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NCBI Updates: BLAST, HMM, and More!

Fri, 26 Apr 2024 10:00:32 -0500

The Latest NCBI Updates

Cleaner BLAST Databases for More Accurate Results

Do you use BLAST to identify a sequence or the evolutionary scope of a gene? We now use NCBI quality assurance tools to systematically remove misleading sequences from the default nucleotide (nt) and protein (nr) BLAST databases.

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NCBI Hidden Markov Models (HMM) Release 15.0 Now Available!

Download release 15.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP)! Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package.

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Now Available! Updated Bacterial and Archaeal Reference Genomes Collection

Download the updated bacterial and archaeal reference genome collection! We built this collection of 19,328 genomes by selecting the “best” genome assembly for each species among the 350,000+ prokaryotic genomes in RefSeq (except for E. coli for which two assemblies were selected as reference).

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Join NCBI at Biology of Genomes 2024

Are you attending the Biology of Genomes meeting in Cold Spring Harbor? Visit NCBI's Nuala O'Leary, PhD, at her poster session on May 7 at 7:30 pm ET and learn more about NCBI Datasets.

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PubChem Periodic Table

Need a versatile periodic table for your classroom? Check out the PubChem Periodic Table! PubChem has a periodic table with interactive graphs of atomic and chemical properties and downloadable data.

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NCBI Updates: RefSeq, Conserved Domain Database, and More!

Fri, 19 Apr 2024 09:30:14 -0500

The Latest NCBI Updates

Reminder! Upcoming Changes to Virus Data Resources at NCBI

As part of our ongoing effort to enhance your experience and modernize our services, several of our legacy virus-related web resources will be replaced by NCBI Virus – our community portal for viral sequence data effective June 2024.

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Browse Taxonomy Records with NCBI Datasets

NCBI Datasets is excited to introduce new features to our Taxonomy pages making it easier for you to access, browse, and download taxonomic information about organisms at any taxonomic level.

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New RefSeq Annotations Now Available

In February and March, the NCBI Eukaryotic Genome Annotation Pipeline released forty-six new annotations in RefSeq! View the full list of annotated eukaryotes available in the Genome Data Viewer (GDV) browser.

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Conserved Domain Database (CDD) Version 3.21 Now Available!

Check out the newly released CDD version 3.21 containing 1,174 new or updated NCBI-curated domains. Updated content is available on the CDD FTP site.

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Significant Updates Coming to the NCBI Datasets APIs and Command-Line Tools

Reminder! We are updating the NCBI Datasets application programming interfaces (APIs). Effective June 2024, NCBI Datasets will deprecate older API and CLI versions.

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NCBI Updates: GTR, NCBI Datasets, and More!

Fri, 12 Apr 2024 09:30:19 -0500

The Latest NCBI Updates

NCBI Datasets: Download Sequence Data and Metadata

Reminder! Effective June 2024, NCBI Datasets will replace the legacy Genome and Assembly web resources. NCBI Datasets is a continually evolving platform designed to provide easy and intuitive access to NCBI’s sequence data and metadata.

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Easy Access to Genetic Test Information with the NIH Genetic Testing Registry (GTR)

We have made some exciting updates to the NIH Genetic Testing Registry (GTR) to give you a more modern, easier-to-navigate display of genetic test information. We encourage you to check out our latest improvements and let us know what you think.

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NCBI Publication Now Available in PubMed Central (PMC)

Check out our NEW PUBLICATION now available in PMC! NCBI worked with industry and academic partners as part of the NIH ACTIV TRACE program to identify ways to ensure variant calling results are consistent across workflows.

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Explore Chemical Information in PubChem

Do you know what chemical ingredients are in green tea leaves? With PubChem, you can quickly find chemical information from authoritative sources. Discover more about green tea leaves and other compounds.

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NCBI Updates: ClinVar, GenBank, and More!

Fri, 05 Apr 2024 10:00:37 -0500

The Latest NCBI Updates

Happy Birthday ClinVar!

From its first release in 2013 to today, ClinVar is now a well-established and critical database for clinical genetics with 4M+ submitted records and almost 3M variants!

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BioEd Summit: Crafting Student-Centric Curricula with NCBI Resources

Are you a high school, community college or undergraduate science educator? If so, check out our BioEd Summit at NIH, Aug 5-9, 2024. Develop cutting-edge curriculum featuring real-world data from NCBI!

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New Data Now Available in NCBI's GenBank

The Centers for Disease Control and Prevention (CDC) submitted sequences of a highly pathogenic avian Influenza A (H5N1) virus from a human in Texas.

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NCBI Updates: MedGen, PubMed Central, and More!

Fri, 29 Mar 2024 09:30:13 -0500

The Latest NCBI Updates

MedGen Users, We Want Your Feedback!

Do you use NCBI’s MedGen? If so, then you probably know it’s NCBI’s one-stop-shop for genetic phenotype information. If you use MedGen, we want to hear from you to help us make this resource better meet your needs!

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Preview Upcoming Improvements to PubMed Central (PMC)

PubMed Central (PMC) continues to improve! We invite you to preview upcoming changes, such as an updated article display and an enhanced PMC journal list. Learn more in this NLM Technical Bulletin article.

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DiscoverBMB was a Success!

We had a great time at the American Society for Biochemistry and Molecular Biology DiscoverBMB conference. Thanks to all those who attended our workshop and stopped by our poster. It was a wonderful opportunity to learn and network with other scientists.

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Happy National Physicians Week

It's National Physicians Week! Did you know NCBI has free clinical and genetic resources to help physicians research, diagnose, and treat patients? Check out ClinVar, MedGen, Medical Genetics Summaries (MGS), Genetic Testing Registry (GTR), and more.

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NCBI Updates: PubMed Central (PMC), ClinicalTrials.gov, and More!

Fri, 22 Mar 2024 10:00:43 -0500

The Latest NCBI Updates

Preview Upcoming Improvements to PubMed Central (PMC)

Preview the latest improvements planned for the PMC website! These improvements will become the default in October 2024 and include an updated article display, enhanced PMC journal list, and other features to help you access information quickly and easily.

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Changes to SRA Data Access on the Google Cloud Platform (GCP)

Sequence Read Archive (SRA) data available via the GCP are migrating from multi-region to single region us-east-1. To minimize the impact of this change, we recommend updating your workflow to access SRA data in us-east-1 region as soon as possible.

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ClinicalTrials.gov API Version 2.0 Now Available

The ClinicalTrials.gov API version 2.0 is now available on the modernized ClinicalTrials.gov website. The API, or application programming interface, is a tool to help researchers and developers access the data in ClinicalTrials.gov study records.

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Recommendations for Uniform Variant Calling of SARS-CoV-2 Genome Sequence Across Bioinformatic Workflows

NCBI worked with Industry and Academic Partners as part of the NIH ACTIV TRACE program to identify ways to ensure variant calling results are consistent across workflows. Details are in our new publication.

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Contribute Your Somatic Variation Data to ClinVar

ClinVar is now accepting submissions for somatic variants classified for cancer. We updated the ClinVar website to better support the display of submitted somatic variation data. We encourage you to contribute your somatic data using our new and improved submission template!

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Final Presentations: Building Transparent ML/AI Solutions to Advance Biological Research Codeathon

Did you miss the final presentations from our codeathon, "Building Transparent ML/AI Solutions to Advance Biological Research"? It's not too late – the recording is available now!

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NCBI Updates: RefSeq, MedGen, and More!

Fri, 15 Mar 2024 09:00:53 -0500

The Latest NCBI Updates

Announcing NCBI's First Ever BioEd Summit

Calling all high school, community college, and undergraduate science educators! Join us for a week-long, in-person event on the NIH campus in Bethesda, MD, from August 5-9, 2024, to collaborate with other educators and NCBI experts to create data-driven curricula.

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Now Available: RefSeq Release 223

Check out RefSeq release 223, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets.

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FCS Publication Now Available on PubMed Central (PMC)

Now available on PMC! Check out our latest publication to learn about FCS-GX, part of NCBI’s Foreign Contamination Screen (FCS) tool suite, optimized to identify and remove contaminant sequences in new genomes.

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Learn About Genetic Conditions with MedGen

Attention ACMG 2024 attendees! Learn more about genetic conditions using MedGen. Find disease characteristics, gene information and therapeutic guidelines from authoritative sources. Stop by NCBI's booth #948 at ACMG for more information!

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Explore PubChem for Chemical Information

Ever wonder about the chemical ingredients in chamomile? Check it out at PubChem, where you can find and access a variety of free chemical information and data. You can search chemicals by name, molecular formula, structure, and other identifiers.

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NCBI Updates: NCBI Bookshelf, PubChem, and More!

Fri, 08 Mar 2024 10:00:31 -0600

The Latest NCBI Updates

Foreign Contamination Screen Tool: Now Available in Galaxy

Calling GenBank data submitters! We made improvements to our Foreign Contamination Screen tool. And it is now available in Galaxy making it easier to run for genome cross-species (GX) and adaptor screening.

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Celebrating the Building Transparent ML/AI Solutions for Biological Research Codeathon

NCBI hosted a codeathon from February 26 to March 1, 2024. This virtual event brought together biologists, developers, and data scientists passionate about using responsible AI in biological research. Thanks to our participants who helped make our codeathon a success!

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NCBI Bookshelf: Celebrating Open Education Week

Happy Open Education Week! Did you know you can search "textbooks" on NCBI Bookshelf to browse our collection of 150+ open access textbooks on biomedical topics? Use this query: "textbooks"[Resource Type].

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Join NCBI at DiscoverBMB 2024

Join us in San Antonio, TX at DiscoverBMB, March 23-25! NCBI staff will participate in a variety of activities and events, including a workshop on iCn3D and a poster presentation about NCBI resources.

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PubChem Imaging Services

Need to generate a mass spectrometry image? Check out PubChem's image generation services. The ms.cgi is designed to display mass spectrometry images with mass:intensity pair input or a list of mass value(s).

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NCBI Updates: FCS, ClinVar, and More!

Fri, 01 Mar 2024 10:00:38 -0600

The Latest NCBI Updates

Rapid and Sensitive Detection of Genome Contamination at Scale with FCS-GX

New NCBI publication! Learn about FCS-GX, part of NCBI’s Foreign Contamination Screen (FCS) tool suite, optimized to identify and remove contaminant sequences in new genomes.

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Submit Your Somatic Variation Data to ClinVar

NCBI’s ClinVar is now accepting submissions for somatic variants classified for cancer. Make ClinVar as useful for somatic variants as it is for germline by contributing your data!

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NCBI Datasets Workshop at TAGC 2024

Are you attending TAGC 2024? Stop by our hands-on workshop on Saturday, March 9 to get an introduction to NCBI Datasets, a new resource for finding and downloading NCBI data.

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Join NCBI at ACMG 2024

NCBI will be attending the ACMG Annual Clinical Genetics Meeting in Toronto, Canada on March 12-16, 2024. Join us at ACMG (Booth #948) to learn about NCBI products and services, reconnect with peers, and engage in discussions with NCBI staff.

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Reminder! NCBI's Genome Workbench to Retire March 2024

As of March 2024, NCBI’s Genome Workbench will no be supported. We encourage you to check out NCBI web tools that provide subsets of Genome Workbench services.

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NCBI Updates: NCBI Datasets, CGR, and More!

Fri, 23 Feb 2024 10:00:34 -0600

The Latest NCBI Updates

Significant Updates Coming to the NCBI Datasets APIs and Command-Line Tools

As part of our ongoing effort to enhance your experience, we are updating the NCBI Datasets application programming interfaces (APIs). Beginning in June 2024, the v2alpha APIs will be promoted to the stable v2 version.

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Join NCBI at TAGC 2024

We look forward to seeing you in person at The Allied Genetics Conference (TAGC), March 6-10, 2024, in the Washington D.C. metro area. NCBI staff will participate in a variety of activities and events.

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Important Update for ClinVar Users

Support for both the old XML formats has been extended through the end of June 2024. Learn about our effort to better support the display of submitted somatic variation data.

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NCBI Updates: NCBI Datasets, ClinVar, and More!

Fri, 16 Feb 2024 10:00:39 -0600

The Latest NCBI Updates

NCBI Celebrates International Love Data Week

Do you love biological data? Join NCBI in celebrating International Love Data Week! We are proud to provide free and open access to scientific literature and data all year round.

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Annotated Genome of the Night Parrot (Pezoporus occidentalis) Now Available

NCBI has annotated the genome sequence of the Night Parrot (Pezoporus occidentalis) with NCBI’s Eukaryotic Annotation Pipeline (EGAP). The genome and annotation products are now available online through NCBI Datasets.

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Enhancements to ClinVar Now Live

ClinVar has updated its web pages and submission processing to support classifications of somatic variants! Learn about changes to the website, and how you can submit your somatic variants to ClinVar.

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NCBI Updates: RefSeq, PubMed, and More!

Fri, 09 Feb 2024 10:00:37 -0600

The Latest NCBI Updates

New RefSeq Annotations Now Available!

During October to January, the NCBI Eukaryotic Genome Annotation Pipeline (EGAP) released seventy new annotations in RefSeq!

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It's American Heart Month!

Happy American Heart Month! It's a great time to think about reducing risk for cardiovascular disease. In honor of American Heart Month, check out NCBI's clinical and genetic resources on heart disease.

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How PubMed Works: Free Online Classes

How PubMed Works is a series of four 90-minute classes with live demonstrations, hands-on exercises, and Q&A time with PubMed experts. Learn more about these classes and how to register through the NLM Technical Bulletin.

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NCBI Updates: ClinVar, NCBI Datasets, and More!

Fri, 02 Feb 2024 10:00:38 -0600

The Latest NCBI Updates

Happy Groundhog Day!

Do we have 6 more weeks of winter upon us? In celebration of Groundhog Day, check out our taxonomy page for the Marmota monax, also known as the groundhog or the woodchuck.

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Enhancements to ClinVar Website Now Live

We updated the ClinVar website as part of our effort to better support the display of submitted somatic variation data. Check out what's changed!

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HomoloGene Now Redirects to NCBI Datasets Gene

A new way to view and download related genes! HomoloGene now automatically redirects to the NCBI Datasets Gene page giving you easy access to up-to-date sequence and homology data.

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Discover, Retrieve, and Analyze Sequence Data with NCBI Virus

'Tis the season for colds and flu! Dive into the world of viruses with NCBI Virus to discover, retrieve, and analyze sequence data for the culprits behind these sniffles!

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NCBI Updates: SciENcv, PGAP, and More!

Fri, 26 Jan 2024 10:00:23 -0600

The Latest NCBI Updates

New SciENcv Tutorial Video

Learn how to create, share, and maintain NSF approved biographical sketches to use for your proposal submission with our new step-by-step tutorial video.

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PAG 31 was a Success!

We had a great time connecting with other researchers and colleagues at PAG 31! NCBI had presentations, posters, meet-the-expert talks, and a special NCBI Genome Resources workshop. Thanks to all the participants!

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Full Text Article Now Available in PubMed Central (PMC)

NCBI recently published an article in the Nucleic Acids Research journal and now it's available in PMC! Learn more about RefSeq and the Prokaryotic Genome Annotation Pipeline (PGAP).

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BLAST FASTA Files Will No Longer Be Available on the FTP Site Effective April 2024

In April 2024, the FASTA (sequence text) files of the sequences in the Basic Alignment Search Tool (BLAST) databases will no longer be available on the FTP site. However, you can easily generate FASTA files yourself from the formatted BLAST databases.

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NCBI Updates: RefSeq, ClinVar, and More!

Fri, 19 Jan 2024 10:00:22 -0600

The Latest NCBI Updates

ClinVar Updates Coming January 29!

Coming soon! On January 29, we are updating the ClinVar website in order to support the inclusion of submitted somatic variation data. Sample snapshots of upcoming changes are available on Github.

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Virtual Workshop! Unlocking the Power of PubChem: Data Mining for Drug Discovery

Do you have experience with biochemical/biological activity assays methods? If so, you may be interested in our upcoming workshop. Learn more about the power of PubChem!

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RefSeq Release 222 Now Available

Check out RefSeq release 222, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets.

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Download the Updated Bacterial and Archaeal Reference Genome Collection

This collection (18,941 genomes as of Jan 18, 2024) was built by selecting the “best” genome assembly for each species among the 330,000+ prokaryotic genomes in RefSeq (except for E. coli for which two assemblies were selected as reference).

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NCBI Updates: ClinVar, HMM, and More!

Fri, 12 Jan 2024 10:00:32 -0600

The Latest NCBI Updates

HMM Release 14.0 Now Available

Download release 14.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package.

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Coming January 29 to ClinVar! Somatic Variants & Changes to the XML

Do you rely on ClinVar XML files for your application or analytical pipeline? Get ready for XLM format updates coming January 29. You may need to make changes to your tool or pipeline code to continue to use the ClinVar XML.

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Codeathon Application Deadline Extended to January 15

Final opportunity to submit your participant applications for our virtual codeathon. Team projects will include predicting drug resistance and health outcomes, antibody engineering, disease term consolidation, and more.

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PubChem Integrates Information on Minerals

Did you know that PubChem integrates information on minerals? PubChem not only has information on drugs and standard chemicals but also includes information on minerals such as quartz, hematite, feldspar, and galena.

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NCBI Announce - Recent Updates

NCBI Updates: Primer-BLAST, dbGaP, and More!

The Latest NCBI Updates

A Modern ClinicalTrials.gov Website

NCBI Collaborates with Africa CDC for Data Curation Workshop

New Publication: Biomedical Data Repository Concepts and Management Principles

Now Available! Download Primer-BLAST Results

New dbGaP Tutorial Video!

NCBI Updates: ClinVar, PubChem, and More!

The Latest NCBI Updates

Important Update for ClinVar Submitters

New Publication: PubChem Synonym Filtering Process Using Crowdsourcing

Top Questions and Answers about the Transition to the Modernized ClinicalTrials.gov Website

PubMed Update: Related Citation Links in Search Results

Study Record Information Displays in the Modernized ClinicalTrials.gov

NCBI Updates: dbSNP, ClinVar, and More!

The Latest NCBI Updates

Use dbSNP to Access Information on Common and Rare Genetic Variants

Resistance is Futile: A Codeathon to Combat Antimicrobial Resistance

ClinVar Release Now Available

NCBI Updates: ClinicalTrials.gov, Taxonomy, and More!

The Latest NCBI Updates

Marking a Milestone: The Modernized ClinicalTrials.gov Becomes the Singular Website Experience

Upcoming Changes to NCBI Taxonomy Classifications

New Publication! The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes

NCBI at ASM Microbe 2024

PubMed Update: Wildcard Search Improvements

NCBI Updates: GenBank, dbSNP, and More!

The Latest NCBI Updates

New Data Available! Access Avian Influenza A (H5N1) Virus Sequences at NCBI

NCBI & NIAID Join Forces to Co-Host Virtual AMR Codeathon

Update to GenBank Qualifier

Learn How to Use dbSNP

Significant Updates Coming to the NCBI Datasets APIs and Command-Line Tools

NCBI Updates: NCBI Orthologs, CGV, and More!

The Latest NCBI Updates

International Nucleotide Database Collaboration (INSDC) Introduces Enhanced Website

Ortholog Groups Added for ~ 2 Million Insect Genes

New Publication About NCBI's Comparative Genome Viewer (CGV)

NLM Webinar: Modernized ClinicalTrials.gov Update

New Data Added to PubChem

NCBI Updates: RefSeq, Pebblescout, and More!

The Latest NCBI Updates

Join NCBI at the AGSx Symposium

New NCBI Publication! Indexing and Searching Petabase-Scale Nucleotide Resources

NCBI Updates: PGAP, SciENcv, and More!

The Latest NCBI Updates

New! May 2024 Release of Stand-Alone PGAP

Preview of Updated PMC Journal List Now Available

Join NCBI at the NSF Grants Conference

BioEd Summit: Crafting Student-Centric Curricula with NCBI Resources

Job Opening: Director of the National Library of Medicine (NLM)

Happy Public Service Recognition Week 2024!

NCBI Updates: GenBank, ClinicalTrials.gov, and More!

The Latest NCBI Updates

All of Us Research Data Now Available in ClinVar

GenBank Release 260.0 is Available!

NLM Webinar: Modernized ClinicalTrials.gov Update

Automated Lineage Definitions Now Available in NCBI Virus SARS-CoV-2 Variants Overview

MTIX: the Next-Generation Algorithm for Automated Indexing of MEDLINE

NCBI Updates: BLAST, HMM, and More!

The Latest NCBI Updates

Cleaner BLAST Databases for More Accurate Results

Now Available! Updated Bacterial and Archaeal Reference Genomes Collection

Join NCBI at Biology of Genomes 2024

PubChem Periodic Table

NCBI Updates: RefSeq, Conserved Domain Database, and More!

The Latest NCBI Updates

Reminder! Upcoming Changes to Virus Data Resources at NCBI

Browse Taxonomy Records with NCBI Datasets

Significant Updates Coming to the NCBI Datasets APIs and Command-Line Tools

NCBI Updates: GTR, NCBI Datasets, and More!

The Latest NCBI Updates

NCBI Datasets: Download Sequence Data and Metadata

Easy Access to Genetic Test Information with the NIH Genetic Testing Registry (GTR)

NCBI Publication Now Available in PubMed Central (PMC)

Explore Chemical Information in PubChem

NCBI Updates: ClinVar, GenBank, and More!

The Latest NCBI Updates

Happy Birthday ClinVar!