Search
Search Results
-
Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP1) exhibit incretin activity, meaning that they potentiate...
-
Secretion of glucagon, GLP-1 and GIP may be affected by circadian rhythm in healthy males
BackgroundGlucagon is secreted from pancreatic alpha cells in response to low blood glucose and increases hepatic glucose production. Furthermore,...
-
GLP1-GIP receptor co-agonists: a promising evolution in the treatment of type 2 diabetes
Type 2 diabetes represents a growing challenge for global public health. Its prevalence is increasing worldwide, and, like obesity, it affects...
-
Agonists and Antagonists of GIP and GLP-1 Receptors: Recombinant Species-Specific Variants and Mutual Neutralization of Activity
The development of recombinant modified derivatives of human glucose-dependent insulinotropic polypeptide (rmGIP) and glucagon-like peptide 1...
-
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease
BackgroundAgonism at the receptor for the glucose-dependent insulinotropic polypeptide (GIPR) is a key component of the novel unimolecular...
-
Studies on prevalence of bovine gastrointestinal parasites (GIP) in Arghandab district of Kandahar province in Afghanistan
Helminth infections are one of the major constraints on livestock enterprises and cause great economic loss in Afghanistan. There is lack of data...
-
Gas-in-Place (GIP) Variation and Main Controlling Factors for the Deep Wufeng-Longmaxi Shales in the Luzhou Area of the Southern Sichuan Basin, China
The Wufeng-Longmaxi Formation shales with burial depths > 3 500 m in the southern Sichuan Basin are believed to have large shale gas potentials....
-
Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis
This meta-analysis aimed to evaluate changes in GIP after RYGB in obese patients. We searched PubMed, EMBASE, and CENTRAL for relevant studies from...
-
-
Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes
BackgroundIn vitro and in vivo studies have shown that certain cytokines and hormones may play a role in the development and progression of type 2...
-
Efficacy and safety of tirzepatide, dual GLP-1/GIP receptor agonists, in the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
BackgroundGlucose-dependent insulinotropic polypeptide (GIP) and GLP-1 are the main incretin hormones, and be responsible for the insulinotropic...
-
ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP
Attention deficit/hyperactivity disorder (ADHD) is the most common childhood neurodevelopmental disorder. Single nucleotide polymorphisms (SNPs) in...
-
-
Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction
Tirzepatide is the first dual GIP/GLP-1 receptor co-agonist approved for the treatment of type 2 diabetes in the USA, Europe, and the UAE....
-
-
The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect
Incretin hormones are peptides released in the intestine in response to the presence of nutrients in its lumen. The main incretins are glucagon-like...
-
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are regarded as ‘incretins’ working closely to regulate...
-
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical...