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Evaluating the effectiveness of combined T4 and T3 therapy or desiccated thyroid versus T4 monotherapy in hypothyroidism: a systematic review and meta-analysis
BackgroundPersistent symptoms in hypothyroid patients despite normalized TSH levels suggest the need for alternative treatments. This study aims to...
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Free T4 is associated with exenatide-related weight loss in patients with type 2 diabetes mellitus and obesity
BackgroundFactors regarding exenatide-related weight loss have been underrecognized. We aimed to reveal the association between free T4 (fT4) level...
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Robotic surgery for locally advanced T4 rectal cancer: feasibility and oncological quality
For T4 rectal tumours and local recurrences (LR) of rectal cancer, a radical resection beyond TME, sometimes by multi-visceral resection, is...
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Larynxorganerhalt bis zum T4‑Larynxkarzinom?
Could primary chemoradiotherapy (pCRT) possibly be viewed as an alternative standard therapy to upfront total laryngectomy (TL)? According to the new...
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Neck Dissection in cT3/T4 Mucoepidermoid Carcinoma of the Oral Cavity and Oropharynx
Previous research has reported high occult nodal metastases rates for T3/T4 mucoepidermoid carcinoma (MEC) of the oropharynx (OP) and oral cavity...
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Safe and curative modified two-stage operation for T4 esophageal cancer after definitive chemoradiotherapy: a case report
BackgroundThe prognosis of esophageal cancer (EC) with organ invasion is extremely poor. In these cases, definitive chemoradiotherapy (CRT) followed...
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Prophylactic Central Compartment Dissection on the Long-Term Outcome of Advanced (N0-T3/T4) Papillary Thyroid Cancer
AimTo see whether prophylactic central compartment dissection is recommended for advanced papillary thyroid cancer or as part of selective neck node...
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Effect of radiation therapy on patients with stage T3 or T4 malignant phyllodes tumors: a retrospective observational study based on SEER
PurposeAmong all primary breast tumors, malignant phyllodes tumor of the breast (MPTB) make up less than 1%. In the treatment of phyllode tumors,...
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Interpretation of TSH and T4 for diagnosing minor alterations in thyroid function: a comparative analysis of two separate longitudinal cohorts
BackgroundMinor alterations in thyroid function are frequent, and interpretation of thyroid function tests in the individual patient can be...
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Prognostic value of MR-detected mandibular nerve involvement: potential indication for future individual induction chemotherapy in T4 nasopharyngeal carcinoma
PurposeTo investigate the prognostic significance of MR-detected mandibular nerve involvement (MNI) and its value for induction chemotherapy (IC)...
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Surgical resection margin for T3–T4 primary acral melanoma: a multicenter retrospective cohort study
Although the National Comprehensive Cancer Network (NCCN) guidelines include clear recommendations for the appropriate resection margins in non-acral...
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Selective local postoperative radiotherapy for T3–T4 N0 laryngeal cancer
PurposeWe aimed to investigate the appropriate postoperative radiotherapy dose and selective volume in T3–4 N0 laryngeal cancer patients treated with...
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What is the Risk for Peritoneal Metastases and Survival Afterwards in T4 Colon Cancers?
BackgroundPatients with T4 colon adenocarcinomas have an increased risk of peritoneal metastases (PM) but the histopathologic risk factors for its...
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Association between maternal age and sex-based neonatal free triiodothyronine levels
BackgroundAdvanced maternal age may affect the intrauterine environment and increase the risk of neurodevelopmental disorders in offspring. Thyroid...
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Molecular identification, phylogenetic analysis and histopathological study of pathogenic free-living amoebae isolated from discus fish (Symphysodon aequifasciatus) in Iran: 2020–2022
Free-living amoebae (FLA) are capable of inhabiting diverse reservoirs independently, without relying on a host organism, hence their designation as...
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Lymph Node Metastases and Associated Recurrence-Free Survival in Microsatellite Stable and Unstable Colon Cancer
BackgroundIn contrast to microsatellite stable (MSS) colon cancer, predictors of lymph node metastases and their association with recurrence are not...
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Textbook outcome in colon carcinoma: implications for overall survival and disease-free survival
BackgroundTextbook outcome (TO) is a multidimensional quality management tool that uses a set of traditional surgical measures to reflect an "ideal"...
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Systemic inflammation score as a preoperative prognostic factor for patients with pT2–T4 resectable gastric cancer: a retrospective study
BackgroundSystemic inflammation has been reported to be associated with cancer progression and metastasis. Systemic inflammation score (SIS),...
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Effect of oxaliplatin in elderly colon cancer patients with pathological T4 and/or N2 disease: a multicenter, propensity score-matched analysis
PurposeAlthough adjuvant chemotherapy (AC) using fluoro-pyrimidine and oxaliplatin (FU + oxaliplatin) is recommended after curative resection for...
