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Research Letter
January 22, 2024

Concomitant Medications for Progressive Supranuclear Palsy: A Secondary Analysis of a Randomized Clinical Trial

Author Affiliations
  • 1Departments of Molecular and Cellular Biology and Statistics, Harvard University, Cambridge, Massachusetts
  • 2Population Health Research Institute, Center for Health Care Research and Policy, MetroHealth Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio
  • 3Edmond J. Safra Program in Parkinson’s Disease, Rossy Progressive Supranuclear Palsy Centre, Movement Disorders Clinic, Krembil Brain Institute, Toronto Western Hospital, University Health Network and Division of Neurology, University of Toronto, Toronto, Ontario, Canada
  • 4Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey
  • 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 6Memory and Aging Center, Department of Neurology, University of California, San Francisco
  • 7Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
JAMA Neurol. 2024;81(3):295-297. doi:10.1001/jamaneurol.2023.5215

There are currently no approved therapies for progressive supranuclear palsy (PSP).1-3 In this post hoc secondary analysis of a phase 2/3 randomized clinical trial of davunetide for PSP (NCT01110720),4 we examined PSP progression outcomes for all included medication classes.

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